Evidence map›Paper›PMID 41754823›Full record

ReviewPharmaceuticals (Basel, Switzerland)2026

Cefepime and New Cefepime/Beta-Lactamase Inhibitor Combination for the Treatment of Gram-Negative Bacteria: Chemical Structure and Mechanism of Action, Microbiological Target, Clinical Use and PK/PD Characteristics.

Davide Carcione, Gioconda Brigante, Antonella Carducci, Jari Intra, Simone Ambretti, Floriana Campanile, Gabriele Arcari, Nicasio Mancini, Dario Cattaneo, Floriana Gona and 7 more

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Phylogenetic Relationships and Structural Conservation ofInternational journal of molecular sciences · 2026
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Davide CarcioneLaboratory of Clinical Microbiology and Virology, ASST Valle Olona, 21013 Gallarate, VA, Italy.ORCID 0000-0003-4411-0407
Gioconda BriganteLaboratory of Clinical Microbiology and Virology, ASST Valle Olona, 21013 Gallarate, VA, Italy.
Antonella CarducciLaboratory of Clinical Microbiology and Virology, ASST Valle Olona, 21013 Gallarate, VA, Italy.
Jari IntraClinical Chemistry Laboratory, Fondazione IRCCS San Gerardo Dei Tintori, 20900 Monza, Italy.ORCID 0000-0003-0978-9573
Simone AmbrettiMicrobiology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-8358-339X
Floriana CampanileDepartment of Biomedical and Biotechnological Sciences, Section of Microbiology, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-8405-5425
Gabriele ArcariLaboratory of Medical Microbiology and Virology, Department of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy.
Nicasio ManciniLaboratory of Medical Microbiology and Virology, Department of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy.
Dario CattaneoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 MI, Italy.ORCID 0000-0003-1512-6530
Floriana GonaDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy.ORCID 0000-0003-2680-5176
Mariagrazia PerilliDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0001-7370-1455
Alessandra PiccirilliDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Nicholas GeremiaUnit of Infectious Diseases, Department of Clinical Medicine, Ospedale "dell'Angelo", 30174 Venice, Italy.ORCID 0000-0001-7988-5419
Verena ZerbatoInfectious Disease Unit, Trieste University Hospital (ASUGI), 34125 Trieste, Italy.ORCID 0000-0002-9204-032X
Stefano Di BellaInfectious Disease Unit, Trieste University Hospital (ASUGI), 34125 Trieste, Italy.ORCID 0000-0001-6121-7009
Giovanna Maria NicolòMicrobiology and Virology Unit, Great Metropolitan Hospital "Bianchi-Melacrino-Morelli", 89100 Reggio Calabria, Italy.ORCID 0009-0006-8817-2123
Luigi PrincipeMicrobiology and Virology Unit, Great Metropolitan Hospital "Bianchi-Melacrino-Morelli", 89100 Reggio Calabria, Italy.ORCID 0000-0002-2000-5322

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global spread of multidrug-resistant (MDR) Gram-negative bacteria, particularly extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing

Indexed as

cefepimeenmetazobactamnacubactamPK/PD featurestaniborbactamzidebactamβ-lactam/β-lactamase inhibitor (BL/BLI) combinations

Identifiers

PMID41754823
PMCPMC12944649

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.