The Genetic Mosaic of Depression: Linking Polymorphisms to Neuroplasticity and Stress Regulation.

Aneta Bednářová, Emma Szilassyová, Dominika Jarčušková, Daniel Múdry, Terézia Kisková-Šimková

Abstract readReview

In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aneta Bednářová2nd Department of Psychiatry, Faculty of Medicine, Pavol Jozef Šafárik University and Louis Pasteur University Hospital, Rastislavova 43, 04190 Košice, Slovakia.ORCID 0000-0001-5130-2533

Emma Szilassyová2nd Department of Psychiatry, Faculty of Medicine, Pavol Jozef Šafárik University and Louis Pasteur University Hospital, Rastislavova 43, 04190 Košice, Slovakia.

Dominika Jarčušková1st Department of Psychiatry, Faculty of Medicine, Pavol Jozef Šafárik University and Louis Pasteur University Hospital, Trieda SNP 1, 04011 Košice, Slovakia.

Daniel MúdryB.Elite, Trieda SNP 339/88, 04011 Košice, Slovakia.

Terézia Kisková-ŠimkováDepartment of Pathology, Faculty of Medicine, Pavol Jozef Šafárik University, Rastislavova 43, 04190 Košice, Slovakia.ORCID 0000-0003-1184-9790

Funding

Ministry of Education, Research, Development and Youth (KEGA) of the Slovak Republic KEGA 001UPJŠ-4/2024 and 003UPJŠ-4/2024Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic and the Slovak Academy of Sciences (VEGA) 1/0648/25Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic and the Slovak Academy of Sciences (VEGA) 1/0702/25

6 · The paper itself

Abstract

The origins of major depressive disorder (MDD) are complex, involving both environmental influences and a substantial genetic contribution. Genetic polymorphisms have been implicated in modulating susceptibility, disease course, and treatment response, yet findings are often modest, population-dependent, and sometimes inconsistent. This narrative review synthesizes current evidence on genetic variants associated with MDD, highlighting well-replicated results while distinguishing exploratory or emerging findings. Key systems reviewed include serotonergic (

Indexed as

depressiongenetic polymorphismsgeneticsheritabilitymajor depressive disorder (MDD)psychiatric genetics

Identifiers

PMID41754876

DOI10.3390/ph19020336

PMCPMC12944579

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.