ArticleSensors (Basel, Switzerland)2026
Label-Free Detection of HeLa Cells Activity Excited by Blue LED.
Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This paper investigates a novel optical method that uses a high-responsivity a-Si:H photodiode for label-free detection of luminescence from HeLa cervical cancer cells excited by a blue LED. We examine the energy distribution of the energy-gap density of states (DOS) from the photodiode's long-time transient current, which shows exponential decay kinetics in the HeLa cell reaction. We analysed the transient response of a-Si:H p-i-n photodiode upon the illumination of the analyte with a pulsed blue LED light to better understand the HeLa cells activity and the fundamental defect kinetics processes in the a-Si:H material. Results suggest that the characteristic very low-level, time-varying light response of HeLa cells is due to chemiluminescence within cells, resulting from the reaction between nitric oxide (NO) and hydrogen peroxide (H
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