Evidence map›Paper›PMID 41755367›Full record

SynthesisObesity reviews : an official journal of the International Association for the Study of Obesity2026

Effects and Dose-Response Relationship of High-Intensity Interval Training on Cardiometabolic Risk in Individuals With Overweight and Obesity: A Systematic Review and Meta-Analysis.

Gaoning Zhang, Mingjing Zhang, Peiqiang Peng, Ruimeng Chao, Ruixue Jiang, Yi Liu, Ting Wang, Lijing Zhao, Xuejiao Lv, Yanwei Du

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gaoning ZhangDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Mingjing ZhangInstitute of Orthopaedic & Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, London, UK.
Peiqiang PengDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Ruimeng ChaoDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Ruixue JiangDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Yi LiuSchool of Nursing, Jilin University, Changchun, Jilin Province, China.
Ting WangDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Lijing ZhaoDepartment of Rehabilitation, School of Nursing, Jilin University, Changchun, Jilin Province, China.
Xuejiao LvDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Yanwei DuDepartment of Rehabilitation, School of Nursing, Jilin University, Changchun, Jilin Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIndividuals with overweight and obesity exhibit elevated cardiometabolic risks. While high-intensity interval training (HIIT) demonstrates potential in improving cardiometabolic health, evidence-based recommendations for optimal HIIT protocols remain uncertain. This study aimed to explore the effects of HIIT on cardiometabolic risk in individuals with overweight and obesity and to characterize dose-response relationships of HIIT programming variables.

methodsA systematic search of five databases (PubMed, Embase, Cochrane Library, Web of Science, Scopus) identified 19 randomized controlled trials comprising 24 intervention groups. The risk of bias was evaluated using the Cochrane Collaboration Tool. Relevant data were extracted, and a meta-analysis was performed using RevMan5.4 software.

resultsMeta-analysis demonstrated that HIIT significantly improved cardiorespiratory fitness (CRF) (standardized mean difference [SMD] = 1.18) and reduced TG (SMD = -0.40) compared to nonexercising controls. Subgroup analyses revealed greater CRF improvements with interventions ≥ 8 weeks, work/rest intervals ≥ 90 s, and high-volume long-interval protocols. Total cholesterol (TC) reductions were significant under work/rest intervals ≥ 90 s (SMD = -1.67) and high-volume protocols (SMD = -2.15). Maximal triglycerides (TG) benefits occurred with work/rest intervals ≥ 90 s (SMD = -0.64) and high-volume protocols (SMD = -0.72). However, HIIT showed no significant effects on body composition, blood pressure, glucose, or high-density lipoprotein/low-density lipoprotein cholesterol.

conclusionHIIT is an effective strategy to reduce cardiometabolic risk (CRF, lipid metabolism) in individuals with overweight and obesity, with a preliminary dose-response relationship observed between training variables and outcomes. Future studies should optimize protocols and confirm sustained benefits.

Indexed as

Cardiovascular DiseasesHigh-Intensity Interval TrainingObesityOverweightCardiometabolic Risk FactorsCardiorespiratory FitnessHumansRandomized Controlled Trials as Topiccardiometabolic riskdose–response relationshiphigh‐intensity interval trainingobesity

Identifiers

PMID41755367
PMCPMC13371801

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.