Evidence map›Paper›PMID 41755554›Full record

ArticleHuman brain mapping2026

Frequency-Resolved Cortical Functional Connectivity Across the Adult Lifespan.

Santeri Ruuskanen, Juan Camilo Avendano-Diaz, Mia Liljeström, Lauri Parkkonen

Abstract read
In one paragraph

Article in Human brain mapping, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Santeri RuuskanenDepartment of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland.ORCID https://orcid.org/0009-0007-6754-5979
Juan Camilo Avendano-DiazDepartment of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland.ORCID https://orcid.org/0000-0003-0436-4955
Mia LiljeströmDepartment of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland.
Lauri ParkkonenDepartment of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland.

Funding

Scalable Software for Distributed Processing and Visualization of Multi-Site MEG/EEG DatasetsR01NS104585 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MATTI HAMALAINEN · 2018 to 2026
$4.3M
Business Finland DIGIMIND 7981/31/2022Helsinki Uusimaa Regional CouncilNINDS NIH HHS R01NS104585Norman Loveless Memorial FundSvenska KulturfondenUK Biotechnology and Biological Sciences Research Council BB/H008217/1UK Medical Research Council and University of Cambridge
6 · The paper itself

Abstract

The operation of the human brain relies on functional networks enabled by inter-areal oscillatory synchronization between neuronal populations. Although disruptions in this functional connectivity are associated with brain disorders, evidence on its healthy age-dependent variation and behavioral relevance remains limited. Utilizing magnetoencephalography (MEG) recordings from 576 adults aged 18-87 years, we investigated the evolution of resting-state functional connectivity (rs-FC) across the healthy adult lifespan. We observed age-related, frequency-specific changes in widespread cortical networks. Alpha-band (8-13 Hz) rs-FC decreased, while delta (1-4 Hz), theta (4-8 Hz), and gamma-band (40-90 Hz) rs-FC increased with age. Beta-band (13-30 Hz) rs-FC followed a non-linear trajectory, peaking in middle age. The global delta, theta, alpha, and beta-band patterns differed from concurrent changes in oscillatory power, underscoring their dissociable contributions. Notably, reduced beta-band rs-FC was associated with increased sensorimotor attenuation, indicating that changes in rs-FC are behaviorally relevant for sensorimotor function. These findings advance our understanding of healthy brain aging and highlight a link between resting-state brain activity and sensorimotor integration.

Indexed as

AgingBrain WavesCerebral CortexConnectomeNerve NetAdolescentAdultAgedAged, 80 and overFemaleHumansMagnetoencephalographyMaleMiddle AgedNeural PathwaysYoung Adultagingbrain oscillationsfunctional connectivitylifespanmagnetoencephalographymegresting‐statesensorimotor attenuation

Identifiers

PMID41755554
PMCPMC12946715

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.