Evidence map›Paper›PMID 41755693›Full record

ReviewActa physiologica (Oxford, England)2026

pH-Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma.

Albrecht Schwab, Micol Rugi, Pawel Swietach, Wiktoria Błaszczak, Ivana Novak, Ganga Deshar, Stine Falsig Pedersen, Renata Ialchina, Albin Sandelin, Jiayi Yao and 28 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Albrecht SchwabInstitut für Physiologie II, University of Münster, Münster, Germany.ORCID https://orcid.org/0000-0002-9280-2099
Micol RugiInstitut für Physiologie II, University of Münster, Münster, Germany.
Pawel SwietachDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Wiktoria BłaszczakDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Ivana NovakSection for Cell Biology and Physiology Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Ganga DesharSection for Cell Biology and Physiology Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Stine Falsig PedersenSection for Cell Biology and Physiology Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Renata IalchinaSection for Cell Biology and Physiology Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Albin SandelinThe Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Jiayi YaoThe Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Stephan J ReshkinDepartment of Biosciences, Biotechnology and Environment, University of Bari, Bari, Italy.
Rosa A CardoneDepartment of Biosciences, Biotechnology and Environment, University of Bari, Bari, Italy.ORCID https://orcid.org/0000-0002-2011-9135
Tiago M A CarvalhoDepartment of Biosciences, Biotechnology and Environment, University of Bari, Bari, Italy.
Annarosa ArcangeliDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.
Rayhana BouazziDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.
Franco N D'AlessandroDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.
Natalia PrevarskayaLaboratory of Cellular Physiology (INSERM U1003), University of Lille, Lille, France.
Madelaine M AuderoLaboratory of Cellular Physiology (INSERM U1003), University of Lille, Lille, France.
Halima Ouadid-AhidouchLaboratory of Cellular and Molecular Physiology, University of Picardie Jules Verne, Amiens, France.
Julie SchnipperLaboratory of Cellular and Molecular Physiology, University of Picardie Jules Verne, Amiens, France.
Luis A PardoMax Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Xiaoyi ShiMax Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Frauke AlvesMax Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Jakub MitręgaMax Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Anna TrauzoldInstitute for Experimental Cancer Research, Christian-Albrecht-Universität Kiel, Kiel, Germany.
Sofie E HagelundInstitute for Experimental Cancer Research, Christian-Albrecht-Universität Kiel, Kiel, Germany.
György PanyiDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Marco CozzolinoDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Clemens M W G LöwikDepartment of Radiology and Nuclear Medicine, Erasums University Medical Center, Rotterdam, the Netherlands.
Laura MezzanotteDepartment of Radiology and Nuclear Medicine, Erasums University Medical Center, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0001-5592-8904
Roisin McMorrowDepartment of Radiology and Nuclear Medicine, Erasums University Medical Center, Rotterdam, the Netherlands.
Andreas PahlHeidelberg-Pharma Research GmbH, Ladenburg, Germany.
Torsten HechlerHeidelberg-Pharma Research GmbH, Ladenburg, Germany.
Elena PapacharisiHeidelberg-Pharma Research GmbH, Ladenburg, Germany.
Alessandra Fiorio PlaDepartment of Life Sciences and Systems Biology, Department of Life Sciences and Systems Biology, University of Torino, Turin, Italy.ORCID https://orcid.org/0000-0003-4576-1594
Ildiko SzaboDepartment of Biology, University of Padua, Padua, Italy.
Verena HofschröerInstitut für Physiologie II, University of Münster, Münster, Germany.
Zoltán PethőInstitut für Physiologie II, University of Münster, Münster, Germany.ORCID https://orcid.org/0000-0001-7057-4761

Funding

Deutsche Forschungsgemeinschaft GRK 2515 (Chembion)Deutsche Forschungsgemeinschaft PE 3917/2-1Marie Skłodowska-Curie Actions Innovative Training Network 813834-pHioniC-H2020-MSCA-ITN-2018
6 · The paper itself

Abstract

aimPancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid-base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal cells. It was postulated that these unique pancreatic pH dynamics can facilitate PDAC initiation and progression through selection of a more aggressive phenotype emerging with PDAC driver mutations.

methodsHere, we summarize evidence that pH-regulatory transport proteins have an important role in shaping the PDAC microenvironment.

resultspH-regulatory transport proteins generate and sense their microenvironment and act as signaling hubs to regulate proliferation, migration, and metabolism, and immune evasion. In this way, transport proteins that are crucial for the normal physiology of the exocrine pancreas are misused and become coerced into playing a pro-cancer role in pancreatic tumor cells, pancreatic stellate cells, or infiltrating immune cells. Experiments with PDAC mouse models revealed a therapeutic potential of targeting pH dynamics, notably by inhibition or genetic ablation of pH-regulatory proteins. It is a consistent finding that these maneuvers have a marked impact on the tumor immune defense and the communication between cancer and immune cells.

conclusionCollectively, we present a case for considering pH-regulating proteins as a therapeutic avenue.

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsSignal TransductionTumor MicroenvironmentAnimalsHumansHydrogen-Ion Concentration

Identifiers

PMID41755693
PMCPMC12946857

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.