ArticleJACS Au2026
E/Z Isomerization-Enabled Conversion from Dual-Carbon to Single-Carbon Insertion into an Aromatic System.
Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A dianionic allene bound to vanadium(iii) enables interconversion between vanadatetrahedranes, vanadacyclobutadienes and deprotiovanadacyclobutadienes.Chemical science · 2026Article
- Article
- Aromaticity and structure switching of cyclopropametallaindole to metallaquinolinium.Nature communications · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
Divergent skeletal modification of aromatic systems is essential for generating molecular diversity, but it remains a significant challenge, typically relying on different individual strategies and starting materials. Herein, we report a tunable dual-to-single carbon insertion into an σ-aromatic metalla-cyclopropene. The key to this approach lies in an E/Z isomerization of two intermediates, in which the E-isomer undergoes dual-carbon insertion and the Z-isomer engages in single-carbon insertion of alkyne into the three-membered ring, proceeding via common [3+2] and unconventional [3+1] pathways, respectively. Both pathways originate from identical reagents, with E-to-Z isomerization of the intermediate achieved by easily modulating the timing of alkyne addition. This work highlights the pivotal role of E/Z isomerization in controlling the reaction selectivity and establishes a new paradigm for temporal control divergent skeletal editing.
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