Evidence mapPaperPMID 41755839Full record

ReviewJACS Au2026

Harnessing AI for Antimicrobial Peptide Innovation against Multidrug Resistance.

João P F Pimentel, Raquel M Quigua Orozco, Samilla Beatriz de Rezende, Lucas Lima, Marlon H Cardoso

Abstract readReview
In one paragraph

Review in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

João P F PimentelS-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande-MS 79117900, Brazil.ORCID https://orcid.org/0000-0003-3111-2219
Raquel M Quigua OrozcoS-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande-MS 79117900, Brazil.ORCID https://orcid.org/0000-0003-1795-8277
Samilla Beatriz de RezendeS-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande-MS 79117900, Brazil.
Lucas LimaS-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande-MS 79117900, Brazil.
Marlon H CardosoS-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande-MS 79117900, Brazil.ORCID https://orcid.org/0000-0001-6676-5362

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) poses a critical global health threat, demanding innovative strategies for drug discovery. Antimicrobial peptides (AMPs) represent promising alternatives, yet traditional experimental identification is limited by cost and scalability. Advances in artificial intelligence (AI), particularly machine learning (ML) and deep learning (DL), have transformed AMP discovery by enabling the accurate prediction, design, and optimization of novel candidates. This perspective highlights recent progress in AI-driven approaches, including predictive models and generative models, which accelerate large-scale peptide screening and functional annotation. We further emphasize the integration of multiomics data and the potential role of emerging technologies, such as quantum computing (QC), in overcoming computational bottlenecks for peptide design. Together, these approaches promise to expand the therapeutic landscape, paving the way toward next-generation peptide-based antimicrobials capable of circumventing resistance mechanisms and addressing urgent clinical needs.

Indexed as

antimicrobial peptidesartificial intelligencedeep learningmachine learningpeptide-based drugs

Identifiers

PMID41755839
PMCPMC12933362

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.