ReviewChronic stress (Thousand Oaks, Calif.)
Reelin, the HPA Axis, and Chronic Stress: Implications for the Neurobiology of Depression.
Review in Chronic stress (Thousand Oaks, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Therapeutic potential of spirulina and its bioactive compound phycocyanin in neuropsychiatric disorders.Molecular biology reports · 2026Review
- Stress-related neuroplasticity and developmental vulnerability in functional neurological disorder: from adverse experience to maladaptive overlearning.Frontiers in molecular neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress and associated dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is central to major depression etiology, as HPA axis hyperactivity and hypercortisolism are common occurrences in individuals with depression. Reelin, an extracellular matrix glycoprotein that plays numerous roles in brain development and function, is downregulated in several neuropsychiatric disorders. Reelin and its receptors are present throughout the HPA axis, and research has found that reelin levels are decreased in animal models of chronic stress in the hypothalamus. There may therefore be roles for reelin in regulating aspects of healthy HPA axis function and for reelin supplementation in restoring various facets of HPA axis function in chronic stress conditions, particularly those associated with HPA axis inhibition and stimulation. This review aims to summarize proposed roles for reelin in HPA axis activity, with a focus on the direct and indirect roles of reelin in restoring HPA axis homeostasis in chronic stress and depression. This review will explore possible interactions between reelin and the HPA axis in chronic stress conditions in order to expand our understanding of the mechanisms underlying the neurobiology of depression.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.