ArticleCurrent research in toxicology2026
Assessment of the carcinogenic potential of automotive gasoline in humans based on mechanistic evidence.
Article in Current research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Liquid gasoline (CAS 86290-81-5) is produced by the fractional distillation of crude oil, and mainly consists of volatile organic compounds; finished automotive gasoline products may also include various additives. The objective of this study was to review mechanistic data including mutagenicity and genotoxicity, along with indications suggestive of immunosuppressive and/or epigenetic activity pertaining to carcinogenicity in humans potentially exposed to automotive gasoline. Six reliable observational studies of fuel station attendants occupationally exposed to gasoline showed a significantly elevated frequency of genetic damage in workers compared to controls and two reliable studies showed no evidence of genetic damage. Fuel station attendants were exposed to a poorly characterized, complex mixture of chemicals, including automotive fuel, diesel, and gasoline engine exhaust. In contrast, animal model and human cell line studies, with a better characterized exposure, did not produce consistent evidence of genotoxic activity. A substantial body of mechanistic data in exposed humans was available; however, limitations in study design and methodological reliability prevented conclusions on whether occupational gasoline exposure leads to immunosuppressive or epigenetic changes. This analysis indicates that the genotoxic activity observed in occupationally-exposed human subjects likely results from the complex environmental exposure that occurs in fuel stations, and cannot be directly attributed to automotive gasoline.
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