ArticleFrontiers in microbiology2026
Ebselen, a promising host-directed therapeutic option against
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Background: As a prevalent food-borne zoonotic pathogen, Methods: To systematically elucidate the mechanism of Ebse efficacy, an in vivo mouse model of acute gastroenteritis induced by Y. pseudotuberculosis and an in vitro macrophage-bacteria interaction model were established. Monitoring mouse survival rates and bioluminescence imaging analysis revealed Ebse's ability against Results and discussion: EbSe improved overall survival and reduced bacterial burden in mice with gastroenteritis. EbSe was found to modulate macrophage polarization, inhibiting apoptosis and excessive inflammation, as detailed in macrophage function and their role in inflammatory responses. Furthermore, EbSe has been shown to protect Raw264.7 cells from
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