Evidence map›Paper›PMID 41756263›Full record

ArticleCritical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine2026

A pilot, parallel-group, blinded, placebo-controlled, randomise

Laurie Showler, Yasmine Ali Abdelhamid, Melissa J Ankravs, Jeremy Goldin, Mark P Plummer, Brianna Tascone, Kathleen Byrne, Andrew Perkins, Kirk Kee, Cara Moore and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Interpreting sleep outcomes in the ICU: Reflections on the DREAM trial.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026
    Article
  2. Interpreting sleep outcomes in the ICU: Reflections on the DREAM trial-Author's reply.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Laurie ShowlerDepartment of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Cnr Grattan Street & Royal Parade, Parkville, Melbourne, Victoria, Australia.
Yasmine Ali AbdelhamidDepartment of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Cnr Grattan Street & Royal Parade, Parkville, Melbourne, Victoria, Australia.
Melissa J AnkravsDepartment of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Cnr Grattan Street & Royal Parade, Parkville, Melbourne, Victoria, Australia.
Jeremy GoldinDepartment of Respiratory and Sleep Disorders Medicine, The Royal Melbourne Hospital, 300 Grattan Street, Parkville, Melbourne, Victoria, Australia.
Mark P PlummerDepartment of Intensive Care, Royal Adelaide Hospital, Port Road, Adelaide, South Australia, Australia.
Brianna TasconeDepartment of Intensive Care, The Royal Melbourne Hospital, 300 Grattan Street, Parkville, Melbourne, Victoria, Australia.
Kathleen ByrneDepartment of Intensive Care, The Royal Melbourne Hospital, 300 Grattan Street, Parkville, Melbourne, Victoria, Australia.
Andrew PerkinsDepartment of Respiratory and Sleep Disorders Medicine, The Royal Melbourne Hospital, 300 Grattan Street, Parkville, Melbourne, Victoria, Australia.
Kirk KeeDepartment of Respiratory and Sleep Disorders Medicine, The Royal Melbourne Hospital, 300 Grattan Street, Parkville, Melbourne, Victoria, Australia.
Cara MooreDepartment of Intensive Care, The Royal Melbourne Hospital, 300 Grattan Street, Parkville, Melbourne, Victoria, Australia.
Barry JohnstonDepartment of Intensive Care, The Royal Melbourne Hospital, 300 Grattan Street, Parkville, Melbourne, Victoria, Australia.
Jeffrey PresneillDepartment of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Cnr Grattan Street & Royal Parade, Parkville, Melbourne, Victoria, Australia.
Adam M DeaneDepartment of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Cnr Grattan Street & Royal Parade, Parkville, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Patients in the intensive care unit (ICU) suffer from disturbed sleep and pharmacological sleep aids are frequently prescribed despite limited data on their efficacy. The objective of this study was to assess the effect of a single nocturnal dose of the benzodiazepine temazepam on sleep duration and quality in ICU patients. Design: Prospective, single-centre, blinded, placebo-controlled, parallel-group, randomised clinical trial. Setting: A tertiary ICU in Australia. Participants: Adult ICU patients whose treating clinician considered that a pharmacological sleep aid was indicated. Interventions: A single weight- and age-adjusted dose of temazepam (10-30 mg) or a matching placebo was administered enterally at 21:00 h. Main outcome measures: The primary outcome was total sleep time between 21:00 and 07:00 h by hourly structured nurse assessment. Secondary outcomes included the evaluation of sleep quality, independently determined by the bedside nurse and patient using the Richards-Campbell Sleep Questionnaire. Results: Between October 2020 and May 2024, 56 patients received temazepam (n = 28) or placebo (n = 28). The mean (standard deviation) total sleep time with temazepam was 349 (120) vs. placebo 291 (124) minutes; difference = 57 min (95% confidence intervals: -11 to 130); p = 0.10. No differences in total Richards-Campbell Sleep Questionnaire sleep quality were observed when assessed by the nurse (57 (17) vs. 49 (23), p = 0.15) or by the patient (50 (28) vs. 51 (23), p = 0.70). Conclusion: A single dose of temazepam was not observed to improve the duration or quality of nocturnal sleep for patients in the ICU. Trial registration: Retrospectively registered with the Australian and New Zealand Clinical Trials Registry on 11th June 2021 (ACTRN 12621000742875).

Indexed as

BenzodiazepinesCritical illnessIntensive care unitSleepSleep-wake disorders

Identifiers

PMID41756263
PMCPMC12933563

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.