Evidence map›Paper›PMID 41756299›Full record

ArticleFrontiers in immunology2026

Cytoprotective role of octacosanol in lipopolysaccharide-induced inflammation.

Jingrong Tang, Zhi-Hong Yang, Wenling Li, Huaitian Liu, Diego Lucero, Denis Sviridov, Olivia White, Julia Kun, Yoh-Suke Mukouyama, Alan T Remaley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jingrong TangLipoprotein Metabolism Laboratory, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States.
Zhi-Hong YangLipoprotein Metabolism Laboratory, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States.
Wenling LiLaboratory of Stem Cell and Neuro-Vascular Biology, Cell and Development Biology Center, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States.
Huaitian LiuLaboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States.
Diego LuceroLipoprotein Metabolism Laboratory, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States.
Denis SviridovLipoprotein Metabolism Laboratory, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States.
Olivia WhiteLipoprotein Metabolism Laboratory, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States.
Julia KunLipoprotein Metabolism Laboratory, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States.
Yoh-Suke MukouyamaLaboratory of Stem Cell and Neuro-Vascular Biology, Cell and Development Biology Center, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States.
Alan T RemaleyLipoprotein Metabolism Laboratory, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation and endothelial dysfunction are key steps in the pathogenesis of atherosclerosis. Octacosanol (C

Indexed as

Anti-Inflammatory AgentsCytoprotectionEndothelial CellsFatty AlcoholsInflammationLipopolysaccharidesAortaCell AdhesionCells, CulturedCytokinesHumansSignal Transduction1-octacosanolAnti-Inflammatory AgentsCytokinesFatty AlcoholsLipopolysaccharidescell-cell junctionsendothelial integrityhuman aortic endothelial cellsinflammationmonocyte adhesionoctacosanolpolicosanol

Identifiers

PMID41756299
PMCPMC12932935

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.