ArticleFrontiers in medicine2026
Association of leuko-glycemic index with mortality in critically ill stroke patients: analysis from the MIMIC-IV database and an institutional cohort.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
Background: The leuko-glycemic index (LGI), combining white blood cell count and blood glucose, reflects systemic inflammation and stress hyperglycemia. Its prognostic value in critically ill stroke patients remains unclear. This study evaluated the association between LGI and mortality using the MIMIC-IV database and an independent institutional cohort. Methods: Patients with acute stroke were identified from MIMIC-IV (version 3.1) and a neurosurgical intensive care unit cohort. LGI was calculated as white blood cell count (×10 Results: A total of 5,267 patients from MIMIC-IV and 424 from the institutional cohort were included. In MIMIC-IV, after multivariable adjustment, patients in the highest LGI quartile had more than threefold higher risk of 28-day mortality compared with the lowest quartile (hazard ratio [HR] 3.259, 95% confidence interval [CI] 2.568-4.138; Conclusion: LGI was significantly associated with mortality in critically ill stroke patients across two independent cohorts and may serve as a simple, readily available biomarker to aid early risk stratification.
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