ArticleFrontiers in cellular and infection microbiology2025
The disturbance of ABC transporters in patients with dengue fever: integration of metabolomics and transcriptomics.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolomic Biomarkers for the Human Diagnosis of Neglected Tropical Diseases: A Systematic Review.Revista da Sociedade Brasileira de Medicina Tropical · 2026Pooled it
- Quorum sensing disruption in Enterobacter spp.: unlocking new therapeutic pathways against multidrug-resistant infections.Antonie van Leeuwenhoek · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: DENV virus (DENV) infection can cause various symptoms and organ damage, even severe dengue fever. However, the underlying host response products and interfering metabolic pathways and mechanisms of DENV infection remain unclear. In this study, we characterized the metabolites and metabolic pathway changes during DENV infection using liquid chromatography- (LC-MS) and gas chromatography-mass spectrometry (GC-MS). And identify the hub differentially expressed targets associated with major metabolism pathways combining transcriptomics. Methods: Plasma from adult patients infected with DENV infection was characterized by untargeted metabolomics using LC-MS and GC-MS. Potential diagnostic biomarkers for dengue fever were indicated using ROC curve analysis. KEGG and GSEA functional enrichment analysis was the strategy to determine the mechanisms of key metabolic pathways in dengue fever. Potential targets were identified by combining transcriptomic in Gene Expression Omnibus (GEO) datasets, and gene databases from GeneCards and the Comparative Toxicogenomics Database (CTD). Results: A total of 41 dengue patients and 23 healthy volunteers were recruited for the study. 61 up-regulated and 136 down-regulated metabolites were identified via untargeted metabolomics. The top10 up-regulated metabolites with high AUC values included trans-cinnamic acid, L-Acetylcarnitine, SM(d17:1/17:0), 1,2,4,5-cyclohexanetetrol, 5-(hydroxymethyl) pyrrolidin-2-one, 1,2,3,4-tetrahydro-6-propanoylpyridine, 2-C-methyl-D-erythritol-4-phosphate, Physalolactone, S-Japonin, and 9-tridecynoic acid, and they were supposed to be the potential diagnostic biomarkers for dengue fever. The disturbance of ATP-binding cassette (ABC) transporters, protein digestion and absorption, aminoacyl-tRNA biosynthesis, mineral absorption, and D-amino acid metabolism were enriched in the metabolic pathways. ABCC5, ABCB1, and ABCG5 were identified as hub differentially expressed targets through transcriptome profiling and protein-protein interaction networks. Conclusions: The current study revealed a shift in metabolite profiles and disturbance in ABC transporters in dengue fever, which can be used for further functional verification.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.