ArticleFrontiers in cardiovascular medicine2026
Association of triglyceride-glucose index and high-sensitivity C-reactive protein with contrast-induced nephropathy after percutaneous coronary intervention in patients with acute coronary syndrome: a retrospective cohort study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Contrast-induced nephropathy (CIN) remains a frequent and serious complication after percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) patients. The triglyceride-glucose (TyG) index, a marker of insulin resistance, and high-sensitivity C-reactive protein (hs-CRP), an inflammatory biomarker, may contribute to CIN development. Methods: This retrospective cohort study included 1,818 ACS patients undergoing PCI between 2017 and 2024. Logistic regression, restricted cubic splines (RCS), and interaction analyses were performed to examine the nonlinear relationships and additive effects of TyG index and hs-CRP on CIN risk. Results: Multivariate logistic regression analysis indicated that both the TyG index (OR = 4.08, 95% CI: 2.95-5.71) and hs-CRP levels (OR = 1.07, 95% CI: 1.05-1.10) were significant independent risk factors for CIN (all Conclusion: Elevated TyG index and hs-CRP levels independently and synergistically increase CIN risk in ACS patients after PCI. These findings highlight the interplay between metabolic and inflammatory pathways in CIN pathogenesis and may help identify high-risk individuals for early preventive strategies.
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