Evidence map›Paper›PMID 41756597›Full record

ArticleFood chemistry: X2026

Machine learning prioritization of antibiotic residues in aquatic foods reveals exposure-driven genotoxic risk mediated by BCL2.

Huangqu Zhu, Kaili Zhou, Yuanzhi Li, Qingqiong Zhou, Mingjun Peng, Xinlan Wu, Xinwu Mao, Qiaoyuan Yang

Abstract read
In one paragraph

Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huangqu ZhuDepartment of Preventive Medicine, School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou, China.
Kaili ZhouDepartment of Preventive Medicine, School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou, China.
Yuanzhi LiDepartment of Preventive Medicine, School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou, China.
Qingqiong ZhouGuangzhou Institute for Food Inspection, 53 Jiejin 2nd Road, Panyu District, Guangzhou, China.
Mingjun PengGuangzhou Institute for Food Inspection, 53 Jiejin 2nd Road, Panyu District, Guangzhou, China.
Xinlan WuDepartment of Preventive Medicine, School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou, China.
Xinwu MaoGuangzhou Institute for Food Inspection, 53 Jiejin 2nd Road, Panyu District, Guangzhou, China.
Qiaoyuan YangDepartment of Preventive Medicine, School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic residues in aquatic foods pose genotoxic risks. Traditional monitoring focuses on individual Maximum Residue Limit (MRL) compliance, often overlooking cumulative multi-residue risks. We developed an interpretable machine learning (ML) framework integrating surveillance data (3719 samples, 17 antibiotics) with mechanistic validation to prioritize risks in Guangzhou (2021-2023). Exposure metrics and in silico hazard predictions were analyzed via clustering and ranking. Enrofloxacin, sulfamethoxazole, and 3-amino-2-oxazolidinone were prioritized, with risk drivers deconstructed via Explainable AI (SHAP). In L-02 hepatocytes, prioritized mixtures reduced viability (70.21 ± 7.49%), increased apoptosis (7.12 ± 2.75%), and induced DNA damage (tail DNA% 5.25 ± 1.03%) (all

Indexed as

Antibiotic residuesFood safetyGenotoxicityMachine learningRegulatory decision-makingRisk prioritization

Identifiers

PMID41756597
PMCPMC12933746

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.