Evidence map›Paper›PMID 41756785›Full record

ArticleFrontiers in cellular and infection microbiology2026

CD169

Marialaura Fanelli, Vita Petrone, Rossella Chirico, Luigi Coppola, Chiara Sorace, Chiara Cipriani, Giovanni Longo, Marco Girasole, Federica Collacchi, Claudia M Radu and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Marialaura FanelliDepartment of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Vita PetroneDepartment of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Rossella ChiricoDepartment of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Luigi CoppolaInfectious Diseases Clinic, Policlinic of Tor Vergata, Rome, Italy.
Chiara SoraceInfectious Diseases Clinic, Policlinic of Tor Vergata, Rome, Italy.
Chiara CiprianiDepartment of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Giovanni LongoIstituto di Struttura della Materia ISM - CNR, Rome, Italy.
Marco GirasoleIstituto di Struttura della Materia ISM - CNR, Rome, Italy.
Federica CollacchiIstituto di Struttura della Materia ISM - CNR, Rome, Italy.
Claudia M RaduThrombotic and Hemorrhagic Diseases Unit Department of Medicine - DIMED University of Padua, Padua, Italy.
Martino Tony MieleDepartment of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Alexandre LucasWe-Met platform, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), plateau We-Met, Inserm UMR1297 and Université Paul Sabatier, Toulouse, France.
Elisabetta TetiInfectious Diseases Clinic, Policlinic of Tor Vergata, Rome, Italy.
Vincenzo MalagninoInfectious Diseases Clinic, Policlinic of Tor Vergata, Rome, Italy.
Marco IannettaInfectious Diseases Clinic, Policlinic of Tor Vergata, Rome, Italy.
Fabrice MalergueGlobal Research Organization, Beckman Coulter Life Sciences, Marseille, France.
Sergio BernardiniDepartment of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Emanuela BalestrieriDepartment of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Loredana SarmatiInfectious Diseases Clinic, Policlinic of Tor Vergata, Rome, Italy.
Sandro GrelliDepartment of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Antonella Minutolo *Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Claudia Matteucci *Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Elevated inflammation and immune dysregulation are the main consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The dysregulated inflammatory state persists after coronavirus disease 2019 (COVID-19), establishing the post-acute sequelae of SARS-CoV-2 infection in individuals with long COVID (LC). The role of CD169 Methods: Blood samples from COV, LC, and healthy donors (HD) were collected at Tor Vergata University Hospital in Rome. Plasmatic EVs were isolated by differential centrifugation and evaluated by flow cytometry and atomic force microscopy (AFM). Leukocyte subpopulations and different sizes of circulating EVs (100-200, 240-500, >500 nm) were characterized for HLA-DR and CD169 expression in COV, LC, and HD through flow cytometry. Serum inflammatory markers were assessed by the ELLA immunoassay system. The analyzed markers were associated with clinical and biochemical parameters in COV and LC. Results: The analysis of HLA-DR Conclusion: Myeloid activation markers and inflammatory cytokines are dynamically expressed between blood cells and circulating extracellular vesicles, underlining multilevel cell-to-cell communications, opening new possibilities to monitor COVID-19 and long COVID-associated sequelae.

Indexed as

COVID-19Extracellular VesiclesHLA-DR AntigensSialic Acid Binding Ig-like Lectin 1AdultAgedFemaleFlow CytometryHumansMaleMiddle AgedMonocytesPost-Acute COVID-19 SyndromeSARS-CoV-2HLA-DR AntigensSialic Acid Binding Ig-like Lectin 1cell-to-cell communicationextracellular vesiclesflow cytometryimmune dysfunctionlong COVIDmyeloid activation markersSARS-CoV-2

Identifiers

PMID41756785
PMCPMC12932623

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.