Evidence map›Paper›PMID 41756835›Full record

ArticlebioRxiv : the preprint server for biology2026

ApoE-Dependent Lipid Handling by Median Eminence Microglia Preserves Myelin Integrity and Metabolic Function.

E R McGrath, A Folick, L J Morrissette, S M Brown Mayfield, V Pham, S N Pillutla, M K Choi, R T Cheang, W R Bolus, A Schwendeman and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

E R McGrathDiabetes Center, University of California, San Francisco, CA, USA.
A FolickDiabetes Center, University of California, San Francisco, CA, USA.
L J MorrissetteDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
S M Brown MayfieldDiabetes Center, University of California, San Francisco, CA, USA.
V PhamDiabetes Center, University of California, San Francisco, CA, USA.
S N PillutlaDiabetes Center, University of California, San Francisco, CA, USA.
M K ChoiDiabetes Center, University of California, San Francisco, CA, USA.
R T CheangDiabetes Center, University of California, San Francisco, CA, USA.
W R BolusDiabetes Center, University of California, San Francisco, CA, USA.
A SchwendemanDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
V NtranosDiabetes Center, University of California, San Francisco, CA, USA.ORCID 0000-0002-2477-0670
S K KoliwadDiabetes Center, University of California, San Francisco, CA, USA.ORCID 0000-0002-7367-1054
M ValdearcosDiabetes Center, University of California, San Francisco, CA, USA.ORCID 0000-0002-5784-2458

Funding

UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Microglia: dietary fat-sensitive mediators of inflammation and metabolic diseaseR01DK103175 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KOLIWAD, SUNEIL KRISHNA · 2015 to 2019
$1.8M
The microbiota-microglia axis in the regulation of metabolic homeostasisR01DK134782 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Martin Valdearcos · 2023 to 2026
$1.6M
Wide-field super-resolution spinning disk confocal microscopeS10OD028611 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTMANN, TORSTEN · 2020 to 2020
$600k
NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK103175NIDDK NIH HHS R01 DK134782NIH HHS S10 OD028611
6 · The paper itself

Abstract

Microglia regulate hypothalamic control of systemic metabolism, but the mechanisms underlying their contribution remain unclear. Here, we identify a distinct apolipoprotein E (

Identifiers

PMID41756835
PMCPMC12934649

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.