ArticlebioRxiv : the preprint server for biology2026
The Olfr151 Odorant Receptor Gene is Resistant to Activation in Embryonic Stem Cells.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
3 authors.
Funding
Abstract
A single allele of any of the ~1100 functional mouse odorant receptor (OR) genes is expressed by mature olfactory sensory neurons (mOSNs) through a poorly understood mechanism of singular gene choice. We were interested in developing an expression system to study OR selection in a mouse embryonic stem cell (mESC) carrying an Olfr151-IRES-CRE knock-in and a CRE-recombination-dependent ROSA26-MTMG reporter. Recombination of the ROSA reporter could not be observed after exposing this mESC to thousands of chemical compounds, including 175 compounds known to interfere with epigenetic regulatory processes nor by transfection with high probability Olfr151 promoter minigenes coexpressing CRE. The only two known regulatory elements that control OR promoters are not olfactory specific. Still, our inability to elicit even leaky CRE recombination in mESCs suggests that a specific transcriptional machinery within the OSN lineage is needed to drive OR promoter activation.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.