Evidence map›Paper›PMID 41756949›Full record

ArticlebioRxiv : the preprint server for biology2026

Adaptive evolution of Topoisomerase II triggers reproductive isolation in Drosophila.

Cara L Brand, Nicholas J Brown, Anirban Dasgupta, Michael Buszczak, Mia T Levine

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cara L BrandDepartment of Biology and Epigenetics Institute, University of Pennsylvania, Philadelphia, PA.
Nicholas J BrownDepartment of Biology and Epigenetics Institute, University of Pennsylvania, Philadelphia, PA.
Anirban DasguptaDepartment of Molecular Biology and Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Michael BuszczakDepartment of Molecular Biology and Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-6361-3654
Mia T LevineDepartment of Biology and Epigenetics Institute, University of Pennsylvania, Philadelphia, PA.

Funding

Causes and functional consequences of chromatin evolutionR35GM124684 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Mia Tauna Levine · 2017 to 2026
$3.5M
Genetic Dissection of Germ Cell Differentiation and FunctionR35GM144043 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Michael Buszczak · 2022 to 2026
$2.1M
Characterization of how mRNA translation influences reproductive agingR01AG079513 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI Michael Buszczak · 2022 to 2026
$1.7M
Training Program in Cell and Molecular BiologyT32GM153602 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MARISA S. BARTOLOMEI, Michael S Marks · 2024 to 2026
$1.6M
Causes and consequences of intra-genomic coevolutionK99GM149943 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BRAND, CARA · 2023 to 2024
$248k
NIA NIH HHS R01 AG079513NIGMS NIH HHS K99 GM149943NIGMS NIH HHS R35 GM124684NIGMS NIH HHS R35 GM144043NIGMS NIH HHS T32 GM153602
6 · The paper itself

Abstract

A fundamental driver of biological diversification is the evolution of reproductive barriers between species. Instability and mis-regulation of repetitive DNA underlie numerous post-zygotic reproductive barriers, yet the molecular mechanisms are unknown. A long-studied genetic incompatibility between

Indexed as

coevolutionDrosophilahybrid lethalitysatellite DNAspeciationTopoisomerase II

Identifiers

PMID41756949
PMCPMC12934790

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.