Evidence map›Paper›PMID 41756953›Full record

ArticlebioRxiv : the preprint server for biology2026

Kevin Cao, Dat Ha, Jesse Hulahan, Lilianna Houston, Gregory Tong, Jiayi Weng, Natasha Huey, Hannah E DeMerit, Pedro Ortega, Rémi Buisson and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kevin CaoDepartment of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92617, USA.ORCID 0009-0000-8399-5389
Dat HaDepartment of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92617, USA.
Jesse HulahanDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92617, USA.ORCID 0009-0004-0567-3252
Lilianna HoustonDepartment of Physics and Astronomy, University of Denver, Denver, Colorado 80210, USA.ORCID 0009-0002-9825-2304
Gregory TongDepartment of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92617, USA.
Jiayi WengDepartment of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92617, USA.ORCID 0009-0002-4294-3456
Natasha HueyDepartment of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92617, USA.
Hannah E DeMeritDepartment of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92617, USA.
Pedro OrtegaDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92617, USA.ORCID 0000-0003-4216-3695
Rémi BuissonDepartment of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92617, USA.ORCID 0000-0002-7196-8209
Kingshuk GhoshDepartment of Physics and Astronomy, University of Denver, Denver, Colorado 80210, USA.ORCID 0000-0003-4976-0986
Thomas F MartinezDepartment of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92617, USA.ORCID 0000-0002-4011-8164

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Molecular Mechanisms of APOBEC-Induced Mutagenesis in CancerR37CA252081 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Remi Buisson · 2021 to 2026
$2.5M
Modeling Conformational Ensembles of the Disordered ProteinsR01GM138901 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GHOSH, KINGSHUK · 2020 to 2024
$1.3M
Deciphering the Interactome and Functions of Disordered MicroproteinsR35GM157126 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Thomas Farid Martinez · 2025 to 2026
$769k
NF-KB regulation by the DNA damage responseR21ES036190 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUISSON, REMI · 2025 to 2025
$432k
Role of APOBEC3B in the Innate Immune ResponseR21AI185033 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Remi Buisson · 2025 to 2026
$425k
NCI NIH HHS P30 CA062203NCI NIH HHS R37 CA252081NIAID NIH HHS R21 AI185033NIEHS NIH HHS R21 ES036190NIGMS NIH HHS R01 GM138901NIGMS NIH HHS R35 GM157126
6 · The paper itself

Abstract

Ribosome biogenesis is the process by which ribosomal RNA (rRNA) and ribosomal proteins are synthesized, processed, and assembled into functional ribosomes. This process begins in the nucleolus, a multiphase liquid condensate. Here, we discover an arginine-rich disordered nucleolar microprotein encoded within the

Indexed as

DExD/H-box RNA HelicaseLiquid-Liquid Phase SeparationMicroproteinNucleolusRibosomal RNA synthesis

Identifiers

PMID41756953
PMCPMC12934739

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.