ArticlebioRxiv : the preprint server for biology2026
A Computational Model of Tumor Interactions with Bone-Resident Cells Predicts Tumor-Type-Specific Responses to Perturbations.
Alexandra Gutierrez Vega, Natalie E Bennett, Erik P Beadle, Saja Alshafeay, Ramcharan Chitturi, Anishka Nagarimadugu, Hrishikesh Villur, Arsh Jaiswal, Julie A Rhoades, Leonard A Harris
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Alexandra Gutierrez VegaInterdisciplinary Graduate Program in Cell & Molecular Biology, University of Arkansas, Fayetteville, AR.
Natalie E BennettProgram in Cancer Biology, Vanderbilt University, Nashville, TN.
Erik P BeadleCenter for Bone Biology, Vanderbilt University Medical Center, Nashville, TN.
Saja AlshafeayInterdisciplinary Graduate Program in Cell & Molecular Biology, University of Arkansas, Fayetteville, AR.
Ramcharan ChitturiDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR.
Anishka NagarimaduguDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR.
Hrishikesh VillurDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR.
Arsh JaiswalDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR.
Julie A RhoadesProgram in Cancer Biology, Vanderbilt University, Nashville, TN.
Leonard A HarrisInterdisciplinary Graduate Program in Cell & Molecular Biology, University of Arkansas, Fayetteville, AR.ORCID 0000-0003-2112-6940 Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MMedical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8MUncovering the molecular networks underlying non-genetic heterogeneity in cancer cell populationsK22CA237857 · NCI · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI HARRIS, LEONARD ALFREDO L. · 2020 to 2022
$563kNCI NIH HHS K22 CA237857NCI NIH HHS P30 CA068485NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284
6 · The paper itselfAbstract
Tumor-induced bone disease (TIBD) arises from a complex interplay between metastatic cancer cells and the bone microenvironment, creating a self-reinforcing "vicious cycle" of bone destruction and tumor growth. Experimental evidence from our group (Buenrostro et al.,
Identifiers
PMID41756997
PMCPMC12934782
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