The Strehler-Mildvan mortality correlation arises from changes in the variability of ageing.

Bruce Zhang, Yiran Zhang, Zibo Gong, David Gems

Abstract readPreprint

In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bruce ZhangInstitute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.ORCID 0000-0003-0956-6142

Yiran ZhangInstitute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.

Zibo GongInstitute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.

David GemsInstitute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.ORCID 0000-0002-6653-4676

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026

$7.5M

NIH HHS P40 OD010440Wellcome Trust

6 · The paper itself

Abstract

As global human life expectancy continues to rise, accompanying increases in healthspan that prevent morbidity expansion become increasingly imperative. Population lifespan can increase in distinct ways, for instance through rectangularisation (steepening) or triangularisation (flattening) of survival curves. These two demographic changes, particularly rectangularisation, occur frequently across human and model organism populations, yet their biological determinants and effects on healthspan and morbidity are largely unknown. Notably, these modes of life-extension occur when parameters of the Gompertz mortality model (capturing exponential age-increases in mortality rate) change inversely, a widely-reported phenomenon known as the Strehler-Mildvan correlation - whose biological basis also remains unexplained. We therefore investigated longitudinal health, morbidity and lifespan in 30

Indexed as

AgeingC. elegansgerospanGompertz equationhealthspanlifespanmortality rateStrehler-Mildvan correlation

Identifiers

PMID41757009

DOI10.64898/2026.02.15.705972

PMCPMC12934673

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.