Evidence map›Paper›PMID 41757018›Full record

ArticlebioRxiv : the preprint server for biology2026

Zebrafish screen of schizophrenia risk genes reveals convergent dysregulation of cholesterol metabolism.

Anna J Moyer, Mary E S Capps, Claire L Conklin, Brandon L Bastien, Verdion Martina, William C Gannaway, Camden E Cummings, Jaqueline A Martinez, Mandy Chen, Gretchen Kioschos and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anna J MoyerDepartment of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA, USA.
Mary E S CappsDepartment of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA, USA.
Claire L ConklinDepartment of Neurobiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Brandon L BastienDepartment of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA, USA.
Verdion MartinaDepartment of Neurobiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
William C GannawayDepartment of Neurobiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Camden E CummingsDepartment of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA, USA.
Jaqueline A MartinezDepartment of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA, USA.
Mandy ChenDepartment of Neurobiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Gretchen KioschosDepartment of Neurobiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Emma G Torija-OlsonDepartment of Neurobiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Morgan C KleinDepartment of Neurobiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Michael D VivianDepartment of Neurobiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Caleb C S CalhounDepartment of Neurobiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Summer B ThymeDepartment of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA, USA.

Funding

Defining the Chemical Perturbome of Neural Development and ActivityDP2NS132107 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI THYME, SUMMER B · 2022 to 2025
$2.3M
Functional Analysis of Schizophrenia-Associated GenesR00MH110603 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI THYME, SUMMER B · 2019 to 2021
$747k
NIMH NIH HHS R00 MH110603NINDS NIH HHS DP2 NS132107
6 · The paper itself

Abstract

Rare coding variants provide a tractable entry point for understanding the molecular mechanisms underlying schizophrenia risk. Here, we generated and characterized zebrafish lines with mutations in the orthologs of >20 human schizophrenia-associated genes, including eight of the top ten SCHEMA genes, genes disrupted in childhood-onset schizophrenia (COS), and genes located within recurrent copy number variants. Whole-brain phospho-Erk activity mapping and behavioral profiling identified phenotypes in multiple mutant lines. We prioritized a protein-truncating mutation in

Identifiers

PMID41757018
PMCPMC12934961

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.