Evidence map›Paper›PMID 41757078›Full record

ArticlebioRxiv : the preprint server for biology2026

Isogenic cortical organoids enable precision targeting of APP variant-specific pathways in Alzheimer's disease.

T Grass, I M Cosacak, A Ordureau, F D Price, S Kavali, A Caldarelli, M N Qiao, B Vardarajan, Joao A Paulo, Michele Marass and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

T GrassGerman Center for Neurodegenerative Diseases e.V. (DZNE), Dresden, Germany.ORCID 0000-0002-0672-4363
I M CosacakTechnische Universität Dresden, Center for Regenerative Therapies Dresden, Dresden, Germany.
A OrdureauCell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
F D PriceDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
S KavaliGerman Center for Neurodegenerative Diseases e.V. (DZNE), Dresden, Germany.
A CaldarelliGerman Center for Neurodegenerative Diseases e.V. (DZNE), Dresden, Germany.
M N QiaoThe Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.
B VardarajanThe Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.
Joao A PauloDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4291-413X
Michele MarassCenter for Systems Biology Dresden, Dresden, Germany.
L L RubinDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
C KizilThe Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.ORCID 0000-0002-8164-9762
N Rodriguez-MuelaGerman Center for Neurodegenerative Diseases e.V. (DZNE), Dresden, Germany.ORCID 0000-0003-1065-1870

Funding

Genetic Epidemiology and Multi-Omics Analyses in Familial and Sporadic Alzheimer's Disease Among Secular Caribbean Hispanics and Religious OrderR01AG067501 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2020 to 2024
$11.7M
Epidemiological Integration of Genetic Variants and Metabolomics Profiles in Washington Heights Columbia Aging ProjectRF1AG066107 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2020 to 2022
$11.4M
NIA NIH HHS R01 AG067501NIA NIH HHS RF1 AG066107
6 · The paper itself

Abstract

Alzheimer's disease (AD) lacks disease-modifying therapies, in part due to the limitations of existing disease models, which have struggled to capture the early pathogenic events leading to neuronal degeneration. Unfortunately, recent therapies targeting hallmarks of AD have proven inefficient in humans, and it is thus necessary to identify alternative targets. Here, by generating an isogenic panel of hiPSC-derived cortical organoids carrying familial AD-associated

Identifiers

PMID41757078
PMCPMC12934581

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.