Evidence map›Paper›PMID 41757231›Full record

ArticleFrontiers in endocrinology2026

Association between platelet-to-albumin ratio and total spine bone mineral density in older adults with thoracolumbar fragility fractures: a retrospective cross-sectional study.

Xinhuan He, Weicong Yin, Dixi Huang, Chuqun Chen, Weiqiang Lai, Siyuan Hu, Xu Li, Kaiqin Gong, Kunrui He, Weile Liu and 5 more

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In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Xinhuan He *Department of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Weicong Yin *Department of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Dixi Huang *Department of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Chuqun ChenDepartment of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Weiqiang LaiDepartment of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Siyuan HuDepartment of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Xu LiDepartment of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Kaiqin GongDepartment of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Kunrui HeDepartment of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Weile LiuDepartment of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Shoubin HuangDepartment of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Shaowei ZhengDepartment of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Jianping ZhengDepartment of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Chunhan SunDepartment of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.
Guowei ZengDepartment of the Orthopaedic, Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Global aging elevates the incidence of thoracolumbar fragility fractures (TLFFs), which are linked to osteoporosis. Platelets (PLT) and albumin influence bone health; the platelet-to-albumin ratio (PAR) is applied in multi-disease research, but it has not yet been applied to patients with TLFF. This study thus explores PAR's association with bone mineral density (BMD). Methods: This retrospective cross-sectional analysis based on a cohort of TLFF patients included 703 elderly TLFF patients from Huizhou First Hospital (2020-2025). BMD was measured, PAR calculated, and grouped; covariates were collected. Subsequently, characterization of the study population, univariate linear regression analyses, and subgroup as well as interaction analyses were carried out. Results: High-PAR groups had higher PLT, lower albumin, and lower BMD. PAR showed a significant negative association with total spine BMD (TS-BMD) even after adjustment; the initial association of neutrophill-to-albumin ratio (NPAR) became non-significant post-adjustment. Conclusion: In elderly TLFF patients, PAR is negatively associated with TS-BMD. As an easily measurable index, PAR may act as a clinical tool.

Indexed as

Blood PlateletsBone DensityLumbar VertebraeOsteoporotic FracturesSerum AlbuminSpinal FracturesThoracic VertebraeAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMalePlatelet CountRetrospective StudiesSerum Albuminalbuminbone mineral densityosteoporosisplateletsplatelet-to-albumin ratiothoracolumbar fragility fractures

Identifiers

PMID41757231
PMCPMC12932198

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.