Evidence map›Paper›PMID 41757272›Full record

ArticleOne health (Amsterdam, Netherlands)2026

Elevated risk of hepatitis E virus infection among sheep smallholders in Xinjiang, China.

Wan-Ting Xu, Yu-Song Ding, Yang-Gui Chen, Ya-Hui Feng, Jun Li, Ji-Guo Jin, Xiang-Nan Wei, Fan Wu, Xing-Yu Wang, Xing-Tao Dang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in One health (Amsterdam, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wan-Ting XuKey Laboratory of Special Environment and Health Research in Xinjiang, School of Public Health, Xinjiang Medical University, Urumqi 830017, China.
Yu-Song DingKey Laboratory of Special Environment and Health Research in Xinjiang, School of Public Health, Xinjiang Medical University, Urumqi 830017, China.
Yang-Gui ChenUrumqi Center for Disease Control and Prevention, Urumqi 830026, China.
Ya-Hui FengKey Laboratory of Special Environment and Health Research in Xinjiang, School of Public Health, Xinjiang Medical University, Urumqi 830017, China.
Jun LiState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830052, China.
Ji-Guo JinKey Laboratory of Special Environment and Health Research in Xinjiang, School of Public Health, Xinjiang Medical University, Urumqi 830017, China.
Xiang-Nan WeiKey Laboratory of Special Environment and Health Research in Xinjiang, School of Public Health, Xinjiang Medical University, Urumqi 830017, China.
Fan WuKey Laboratory of Special Environment and Health Research in Xinjiang, School of Public Health, Xinjiang Medical University, Urumqi 830017, China.
Xing-Yu WangKey Laboratory of Special Environment and Health Research in Xinjiang, School of Public Health, Xinjiang Medical University, Urumqi 830017, China.
Xing-Tao DangKey Laboratory of Special Environment and Health Research in Xinjiang, School of Public Health, Xinjiang Medical University, Urumqi 830017, China.
Guo-Wu ZhangState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830052, China.
Xue-Ying XiangKey Laboratory of Special Environment and Health Research in Xinjiang, School of Public Health, Xinjiang Medical University, Urumqi 830017, China.
Fu-Ye LiKey Laboratory of Special Environment and Health Research in Xinjiang, School of Public Health, Xinjiang Medical University, Urumqi 830017, China.
Wen-Bao ZhangState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830052, China.
Jian-Yong WuKey Laboratory of Special Environment and Health Research in Xinjiang, School of Public Health, Xinjiang Medical University, Urumqi 830017, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis E virus (HEV) is an emerging zoonotic pathogen that infects both humans and domestic animals. Although HEV has been detected in sheep, the risks of transmission along the food chain via the mutton industry chain remain poorly characterized. This study aimed to assess the occupational risk of HEV infection among sheep industry workers. A cross-sectional survey was conducted among sheep workers in various settings, including smallholder farms, slaughterhouses, and retail markets. Serum samples from these workers, as well as from individuals in the general population, were collected and tested for anti-HEV IgM and IgG antibodies using commercial ELISA kits. Risk factors for HEV seropositivity across different occupational environments were analyzed using logistic regression. The seropositivity rate among sheep industry workers was 53.0% (132/249), significantly higher than that in the general population (13.3%, 33/249). Multi-variable analysis revealed a markedly increased risk of HEV infection among smallholder sheep farmers (adjusted OR = 10.1, 95% CI: 6.3-16.3). In contrast, there was no significantly elevated risk among people working in retail markets or slaughterhouses. The results indicate that occupational exposure to sheep is associated with a heightened risk of HEV infection, particularly in smallholder farm settings. Strengthening HEV control measures for HEV in high-risk occupational environments is essential for long-term public health prevention and elimination efforts.

Indexed as

Hepatitis E virusOccupational riskOne healthSeroprevalenceSheep worker

Identifiers

PMID41757272
PMCPMC12933615

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.