Evidence map›Paper›PMID 41757374›Full record

ArticleMolecular therapy. Nucleic acids2026

N1MΨU-modified mRNA vaccines break the mold in fish by enhancing innate immune activation.

Dean Porter, Luc Jouneau, Mathilde Peruzzi, Bertrand Collet, Bernard Verrier, Pierre Boudinot

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Dean PorterUniversité Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France.
Luc JouneauUniversité Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France.
Mathilde PeruzziUniversité Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France.
Bertrand ColletUniversité Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France.
Bernard VerrierAdjuvatis, Batiment Laennec 60, Avenue Rockefeller, 69008 Lyon, France.
Pierre BoudinotUniversité Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Messenger RNA (mRNA) vaccines have revolutionized immunization strategies in mammals, with chemical modifications such as N1-methyl-pseudouridine (N1MΨU) enhancing stability, translation, and reducing innate immune activation. However, the immunological implications of such modifications in non-mammalian species, particularly teleost fish, remain unclear. In this study, we evaluated the innate immune responses elicited by four vaccine platforms: a DNA vaccine, a live attenuated viral hemorrhagic septicemia virus (VHSV), an unmodified mRNA, and an N1MΨU-modified mRNA. All four vaccines encode the G protein of VHSV (G

Indexed as

fishinnate immunityinterferon responsemRNA vaccineMT: Delivery StrategiesN1-methyl pseudouridinerainbow troutRNA sensing

Identifiers

PMID41757374
PMCPMC12934228

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.