Evidence map›Paper›PMID 41757376›Full record

ArticleBrain, behavior, & immunity - health2026

Physical activity-associated extracellular vesicles inhibit inflammagen-induced microglial activation.

Chien-Yu Su, Heng-Juei Hsu, Tzu-Feng Wang, Hong-Lin Chou, Sheng-Feng Tsai, Chu-Wan Lee, Ching-Li Cheng, Yang-Kao Wang, Yu-Min Kuo

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Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chien-Yu SuDepartment of Neurology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, 600566, Taiwan.
Heng-Juei HsuDepartment of Neurosurgery, Tainan Municipal Hospital (Managed by Show Chwan Medical Care Corporation), Tainan, 701033, Taiwan.
Tzu-Feng WangDepartment of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701401, Taiwan.
Hong-Lin ChouDepartment of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701401, Taiwan.
Sheng-Feng TsaiDepartment of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701401, Taiwan.
Chu-Wan LeeDepartment of Nursing, National Tainan Junior College of Nursing, Tainan, 700007, Taiwan.
Ching-Li ChengDepartment of Nursing, National Tainan Junior College of Nursing, Tainan, 700007, Taiwan.
Yang-Kao WangDepartment of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701401, Taiwan.
Yu-Min KuoDepartment of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 701401, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive microglial activation and neuroinflammation are pivotal contributors to the progression of neurodegenerative diseases. Physical activity has emerged as a complementary therapy recognized for its anti-inflammatory effects. Long-term treadmill-induced mandatory physical activity (TMPA), a rodent paradigm modeling exercise with controllable intensity, has been shown to reduce age-related microglial activation, dopaminergic neuron degeneration in the substantia nigra, and motor impairments in mice. However, the mechanisms underlying these effects remain unclear. Given the role of physical activity-induced exerkines in modulating anti-inflammatory responses, this study investigated the effects of plasma-derived extracellular vesicles (EVs) from TMPA-treated animals on inflammagen-induced microglial activation in both

Indexed as

Anti-inflammationExosomesNeuroinflammationParkinson's diseasePhysical activitySubstantia nigra

Identifiers

PMID41757376
PMCPMC12934276

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.