Evidence mapPaperPMID 41757404Full record

ArticleChild development2026

Community threat, positive parenting, and accelerated epigenetic aging: Longitudinal links from childhood to adolescence.

Georgette Metrailer, Karina Tavares, Mikayla Ver Pault, Adamari Lopez, Shane Denherder, Evelyn Hernandez Valencia, Karissa DiMarzio, April Highlander, Sarah M Merrill, Darlynn M Rojo-Wissar and 1 more

Erratum issuedAbstract read
In one paragraph

Article in Child development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Georgette MetrailerDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, United States.
Karina TavaresDepartment of Psychology, University of Rhode Island, Kingston, RI, United States.
Mikayla Ver PaultDepartment of Psychology, University of Rhode Island, Kingston, RI, United States.
Adamari LopezDepartment of Psychology, University of Rhode Island, Kingston, RI, United States.
Shane DenherderDepartment of Psychology, University of Rhode Island, Kingston, RI, United States.
Evelyn Hernandez ValenciaDepartment of Psychology, University of Rhode Island, Kingston, RI, United States.
Karissa DiMarzioDepartment of Psychology, Florida International University, Miami, FL, United States.
April HighlanderDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, United States.
Sarah M MerrillDepartment of Psychology, University of Massachusetts, Lowell, MA, United States.
Darlynn M Rojo-WissarDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, United States.ORCID 0000-0001-7353-1353
Justin ParentDepartment of Psychology, University of Rhode Island, Kingston, RI, United States.

Funding

Fragile Families and Child Wellbeing - Young AdulthoodR01HD036916 · NICHD · PRINCETON UNIVERSITY · 1999 to 2025
$9.4M
Rhode Island IDeA Network of Biomedical Research ExcellenceP20GM103430 · UNIVERSITY OF RHODE ISLAND · 2025 to 2025
$4.1M
ECONOMIC STATUS, PUBLIC POLICY, AND CHILD NEGLECTR01HD039135 · PRINCETON UNIVERSITY · 2000 to 2004
$3.1M
Child Care and Parental Employment in Fragile FamiliesR01HD040421 · COLUMBIA UNIVERSITY TEACHERS COLLEGE · 2002 to 2005
$2.5M
Mindfulness, Optimism and Resilience for Perinatal Health and Empowerment (MORPHE) Trial P20GM139767 · MIRIAM HOSPITAL · 2025 to 2025
$1.2M
Epigenomic mechanisms of risk and resilience: The role of parentingR01MD015401 · NIMHD · UNIVERSITY OF RHODE ISLAND · PI Justin Parent · 2023 to 2024
$446k
Eunice Kennedy ShriverNational Institute of Child Health and Human DevelopmentNational Science Foundation 2146759Network of Biomedical Research ExcellenceNHLBI NIH HHS 1K01HL169495NICHD NIH HHS F31HD106768NICHD NIH HHS L40 HD103048NICHD NIH HHS L40HD103048NICHD NIH HHS T32HD101392NIGMS NIH HHSNIGMS NIH HHS P20GM139767NIH HHS P20GM103430NIH HHS R01HD036916NIH HHS R01HD039135NIH HHS R01HD040421NIMHD NIH HHS R01 MD015401NIMHD NIH HHS R01MD015401Rhode Island Institutional Development Award
6 · The paper itself

Abstract

Early life adversity (ELA) has been linked to accelerated epigenetic aging. While positive parenting is hypothesized to buffer the effects of ELA, its role in mitigating epigenetic age acceleration remains unclear. Data from 2,039 children (49.7% female; 46.7% Black, 26.5% Hispanic, and 19% White non-Hispanic) in the Future of Families and Child Wellbeing Study were included. Home threat, community threat, and parenting were measured from ages 3 to 9 (2001-2010). Epigenetic age acceleration was assessed at ages 9 and 15 (2007-2017). Positive parenting reduced the pace of epigenetic aging in contexts of low, but not high, community threat (β = .026, p = .039). Interventions across multiple socioecological systems may be necessary to prevent the biological embedding of ELA.

Indexed as

Adverse Childhood ExperiencesAgingEpigenesis, GeneticParentingAdolescentChildChild, PreschoolFemaleHumansLongitudinal StudiesMaleadolescenceadversitychildhoodepigenetic agingparenting

Identifiers

PMID41757404
PMCPMC13046079

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.