Evidence map›Paper›PMID 41757484›Full record

ArticleImmunity, inflammation and disease2026

Main Protease From SARS-CoV-2 Dysregulates Glucose Handling in the C2C12 Cell Line In Vitro: A Mechanistic Study.

Praise Tatenda Nhau, Mlindeli Gamede, Andile Khathi, Ntethelelo Sibiya

Abstract read
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In one paragraph

Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Praise Tatenda NhauPharmacology Division, Faculty of Pharmacy, Rhodes University, Makhanda, South Africa.
Mlindeli GamedePhysiology, University of Pretoria, Tshwane, South Africa.ORCID https://orcid.org/0000-0001-5512-1545
Andile KhathiHuman Physiology, University of KwaZulu-Natal, Durban, South Africa.
Ntethelelo SibiyaPharmacology Division, Faculty of Pharmacy, Rhodes University, Makhanda, South Africa.ORCID https://orcid.org/0000-0001-5894-8935

Funding

the National Research Foundation South Africa TTK220318196
6 · The paper itself

Abstract

backgroundThere is evidence demonstrating the risk of developing diabetes mellitus because of SARS-CoV-2 infection. Therefore, further research is needed to determine pathological mechanisms at which SARS-CoV-2 induces diabetes mellitus. This study therefore aims to understand the effect of SARS-CoV-2 Main protease (M

methodsIn this study, C2C12 cell preparations were exposed to different concentrations of M

resultsFollowing 24 h of treatment with SARS-CoV-2 M

conclusionsThe observations suggest that the SARS-CoV-2 M

Indexed as

BetacoronavirusCoronavirus 3C ProteasesCysteine EndopeptidasesGlucoseSARS-CoV-2AnimalsCell LineCell SurvivalCOVID-19Glucose Transporter Type 4Interleukin-6Lipid PeroxidationMiceMuscle, SkeletalProto-Oncogene Proteins c-aktCoronavirus 3C ProteasesCysteine EndopeptidasesGlucoseGlucose Transporter Type 4Interleukin-6interleukin-6, mouseProto-Oncogene Proteins c-aktSlc2a4 protein, mousediabetes mellitusGLUT 4insulininsulin resistanceMproSARS‐COV‐2

Identifiers

PMID41757484
PMCPMC12946929

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.