Evidence map›Paper›PMID 41757739›Full record

ArticleAmerican journal of hematology2026

Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification.

Sara El Aouhel, Vanessa Bellegarde, Stennio Da Silva Faria, Tristan St-Laurent, Estelle Lecluze, Anne-Laure Pham Hung d'Alexandry d'Orengiani, Frédéric Galactéros, Pablo Bartolucci, Marc-André Legault, Guillaume Lettre and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sara El AouhelCHU Sainte-Justine Azrieli Research Center, Montréal, Québec, Canada.
Vanessa BellegardeMontreal Heart Institute, Montréal, Québec, Canada.
Stennio Da Silva FariaCHU Sainte-Justine Azrieli Research Center, Montréal, Québec, Canada.
Tristan St-LaurentCHU Sainte-Justine Azrieli Research Center, Montréal, Québec, Canada.
Estelle LecluzeCHU Sainte-Justine Azrieli Research Center, Montréal, Québec, Canada.
Anne-Laure Pham Hung d'Alexandry d'OrengianiRed Cell Genetic Disease Unit, Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Est, IMRB - U955, Créteil, France.
Frédéric GalactérosRed Cell Genetic Disease Unit, Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Est, IMRB - U955, Créteil, France.
Pablo BartolucciRed Cell Genetic Disease Unit, Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Est, IMRB - U955, Créteil, France.
Marc-André LegaultCHU Sainte-Justine Azrieli Research Center, Montréal, Québec, Canada.
Guillaume LettreMontreal Heart Institute, Montréal, Québec, Canada.
Thomas PincezCHU Sainte-Justine Azrieli Research Center, Montréal, Québec, Canada.ORCID 0000-0002-9412-333X

Funding

CIHR PJT #186159Institut de Valorisation des Données
6 · The paper itself

Abstract

Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD) occurring in ~50% of patients, some presenting frequent episodes. We lack tools to identify patients at high risk of ACS occurrence or frequent episodes. Epidemiological studies have found an association between asthma and ACS, but whether this link is causal is unclear. We used polygenic scores (PGS) to analyze whether the genetic propensity for asthma was associated with ACS and could be used to stratify the risk of ACS. We identified that PGS for asthma (PGS

Indexed as

Acute Chest SyndromeAnemia, Sickle CellAsthmaAdultFemaleFetal HemoglobinGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMaleMiddle AgedProspective StudiesRisk AssessmentRisk FactorsFetal Hemoglobinacute chest syndromeasthmapolygenic scorerisk stratificationsickle cell disease

Identifiers

PMID41757739
PMCPMC13055117

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.