Evidence map›Paper›PMID 41757906›Full record

ArticleMicrobiology spectrum2026

Auranofin and iodoquinol as promising repurposing drugs against filamentous fungi: antifungal activity and cellular alterations.

Mariana Ingrid Dutra da Silva Xisto, Rodrigo Rollin-Pinheiro, Paloma Cristina Malfetano da Rosa, Johnatha de Souza Santos, Nicole Ferreira da Silva Irmão, Julia Almeida Abi Abib, Victor Pereira Rochetti, Yuri de Castro Almeida, Giulia Maria Pires Dos Santos Freitas, Jefferson Cypriano and 1 more

Abstract read
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In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mariana Ingrid Dutra da Silva Xisto *Laboratório de Química Biológica de Microrganismos, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID 0000-0002-1803-6381
Rodrigo Rollin-Pinheiro *Laboratório de Química Biológica de Microrganismos, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID 0000-0002-8316-4670
Paloma Cristina Malfetano da Rosa *Laboratório de Química Biológica de Microrganismos, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Johnatha de Souza Santos *Laboratório de Química Biológica de Microrganismos, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Nicole Ferreira da Silva Irmão *Laboratório de Química Biológica de Microrganismos, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Julia Almeida Abi Abib *Laboratório de Química Biológica de Microrganismos, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Victor Pereira Rochetti *Laboratório de Química Biológica de Microrganismos, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Yuri de Castro Almeida *Laboratório de Química Biológica de Microrganismos, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Giulia Maria Pires Dos Santos Freitas *Laboratório de Química Biológica de Microrganismos, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Jefferson CyprianoUnimicro, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Eliana Barreto-BergterLaboratório de Química Biológica de Microrganismos, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID 0000-0002-8944-9415

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 405934/2022-0Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/200.591/2022, E-26/210.355/2022Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/202.091/2025, E-26/210.527/2025
6 · The paper itself

Abstract

Opportunistic fungal infections have become an increasing health threat, particularly in immunocompromised individuals, due to their high virulence, biofilm-forming capacity, and resistance to conventional antifungals. Given the limited therapeutic arsenal, drug repurposing represents a promising strategy for antifungal discovery. This study evaluated the antifungal activity and mechanisms of auranofin and iodoquinol against filamentous fungi listed as World Health Organization (WHO) priority pathogens, including

Indexed as

Antifungal AgentsAuranofinDrug RepositioningFungiAspergillus fumigatusBiofilmsHumansMicrobial Sensitivity TestsMycosesAntifungal AgentsAuranofinantifungal therapyauranofinfungal infectionsiodoquinolrepurposing drugs

Identifiers

PMID41757906
PMCPMC13055367

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.