Evidence map›Paper›PMID 41758408›Full record

ArticleJournal of gastroenterology2026

Hepatocyte-specific yes-associated protein knockout exacerbates non-alcoholic steatohepatitis by upregulating PCSK9.

Xia Sun, Yu Zhang, Xin Zhang, Qiaohong Qin, Ying Hou, Min Jia, Xingli Su, Yulong Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xia Sun *Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an , 710021, Shaanxi, China.
Yu Zhang *Department of Traditional Chinese Medicine, The First Affiliated Hospital of Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
Xin ZhangInstitute of Basic and Translational Medicine, Xi'an Medical University, Xi'an , 710021, Shaanxi, China.
Qiaohong QinInstitute of Basic and Translational Medicine, Xi'an Medical University, Xi'an , 710021, Shaanxi, China.
Ying HouInstitute of Basic and Translational Medicine, Xi'an Medical University, Xi'an , 710021, Shaanxi, China.
Min JiaInstitute of Basic and Translational Medicine, Xi'an Medical University, Xi'an , 710021, Shaanxi, China. jiamin_jzs@xiyi.edu.cn.
Xingli SuSchool of Basic and Medical Sciences, Xi'an Medical University, Xi'an , 710021, Shaanxi, China. suxingli@xiyi.edu.cn.
Yulong ChenInstitute of Basic and Translational Medicine, Xi'an Medical University, Xi'an , 710021, Shaanxi, China. chenyulong_jzs@xiyi.edu.cn.ORCID 0000-0002-1896-7194

Funding

the Key Scientific Research Plan Project of the Education Department of Shaanxi Province 22JS038the Natural Science Fund of Shaanxi Province 2022JQ-864the Natural Science Fund of Shaanxi Province 2023-JC-YB-753the Natural Science Fund of Shaanxi Province 2024JC-YBQN-0953the Scientific and Technological Innovation team of Xi'an Medical University. 2021TD06the Special Research Plan of the Education Department of Shaanxi Province 22JK0540
6 · The paper itself

Abstract

backgroundNo licensed drugs have been established for the treatment of nonalcoholic steatohepatitis (NASH). Therefore, we aimed to explore the effect of Yes-associated protein (YAP) on NASH to provide a therapeutic target.

methodsWe constructed a mouse model of NASH, consuming either a methionine-choline deficient (MCD) or Gubra Amylin NASH (GAN) diet. Hepatocyte-specific YAP knockout (YAP

resultsHepatic YAP protein levels were increased in NASH models. The YAP deletion reduced hepatic steatosis and exacerbated hepatic inflammation and fibrosis. However, YAP overexpression leads to the opposite NASH phenotype. Furthermore, the MCD or GAN diet-fed YAP

conclusionsOur findings demonstrate that hepatocyte YAP mitigates NASH severity by increasing PCSK9 expression via the OSM-JAK2-STAT3 pathway independent of lipid accumulation. Therefore, hepatocyte YAP may be a promising target for the management of NASH.

Indexed as

Adaptor Proteins, Signal TransducingHepatocytesNon-alcoholic Fatty Liver DiseaseProprotein Convertase 9AnimalsCell Cycle ProteinsDisease Models, AnimalDisease ProgressionMaleMiceMice, Inbred C57BLMice, KnockoutUp-RegulationYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsPcsk9 protein, mouseProprotein Convertase 9Yap1 protein, mouseYAP-Signaling ProteinsHepatocyteNonalcoholic steatohepatitisPCSK9Yes-associated protein

Identifiers

PMID41758408

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.