ArticleJournal of clinical hypertension (Greenwich, Conn.)2026
Association Between NHHR and Future Cardiovascular Disease Among Patients With CKM Stages 0-3: A Nationwide Prospective Cohort Study.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Non-HDL-to-HDL-cholesterol ratio and metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis.BMC gastroenterology · 2026Pooled it
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Authors and funding
7 authors.
Funding
Abstract
The American Heart Association recently proposed the concept of Cardiovascular-kidney-metabolic (CKM) syndrome, emphasizing the interconnections among cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic disorders. The ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) has emerged as a novel lipid marker associated with CVD, but its relevance in individuals with CKM syndrome remains unclear. This study aimed to examine the association between NHHR and incident CVD among adults with CKM stages 0-3 using data from the China Health and Retirement Longitudinal Study (CHARLS). CVD events were defined as self-reported heart disease or stroke. Cox proportional hazards models and restricted cubic spline (RCS) analyses were applied to assess associations, and receiver operating characteristic (ROC) curves evaluated predictive performance. Among 7445 participants (mean follow-up: 80 months), 1476 developed CVD. Each one-unit increase in NHHR was associated with a 4% higher risk of CVD (95% CI: 1.00-1.08). Participants in the highest quartile (Q4) had a 23% higher risk compared with Q1 (HR = 1.23, 95% CI: 1.03-1.47). RCS analysis showed a significant positive linear relationship (P overall = 0.018). NHHR demonstrated the strongest predictive ability for CVD, with consistent results across subgroups. Higher NHHR levels were independently linked to increased CVD risk among individuals with CKM stages 0-3, suggesting NHHR may serve as a simple marker to identify high-risk populations.
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Registered trials
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