Evidence map›Paper›PMID 41758613›Full record

Trial reportAmerican journal of physiology. Renal physiology2026

Acute kidney injury biomarker responses in young and older female adults following mild hypohydration.

Christin Domeier, Austin T Robinson, Matthew C Babcock, Joseph D Vondrasek, Thomas G Bissen, Colleen X Muñoz, Kyle A Smith, Joseph C Watso

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Water intake mediates cross-sectional associations between urinary kidney injury biomarkers and race in emerging adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christin DomeierCardiovascular and Applied Physiology Laboratory, Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0000-0002-3062-5584
Austin T RobinsonDepartment of Kinesiology, School of Public Health, Indiana University, Bloomington, Indiana, United States.ORCID 0000-0001-8250-3952
Matthew C BabcockDivision of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-8047-4411
Joseph D VondrasekCardiovascular and Applied Physiology Laboratory, Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0009-0006-8573-5955
Thomas G BissenCardiovascular and Applied Physiology Laboratory, Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0009-0003-9660-043X
Colleen X MuñozHydration Health Center, University of Hartford, West Hartford, Connecticut, United States.ORCID 0000-0002-3345-9411
Kyle A SmithInstitute of Sports Sciences and Medicine, Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0000-0002-4585-4240
Joseph C WatsoCardiovascular and Applied Physiology Laboratory, Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0000-0001-7840-0643

Funding

Translation CoreP30DK097512 · INDIANA UNIVERSITY INDIANAPOLIS · 2025 to 2025
$1.7M
Neural and Renal Contributions to Hypertension with Androgen Deprivation TherapyK01HL164978 · UNIVERSITY OF COLORADO DENVER · 2025 to 2025
$166k
Time-Efficient Inspiratory Muscle Strength Training as a New Approach to Lower Blood Pressure, Improve Respiratory Function, and Reduce Exertional Dyspnea in Adults with ObesityK01HL160772 · FLORIDA STATE UNIVERSITY · 2025 to 2025
$138k
American Heart Association (AHA) 23CDA1037938American Heart Association (AHA) 25PRE1354834HHS | National Institutes of Health (NIH) K01HL147998HHS | National Institutes of Health (NIH) K01HL160772HHS | National Institutes of Health (NIH) K01HL164978Institute for Successful LongevityNHLBI NIH HHS K01 HL147998NHLBI NIH HHS K01 HL160772NHLBI NIH HHS K01 HL164978NIDDK NIH HHS P30 DK097512
6 · The paper itself

Abstract

Hypohydration reduces kidney function and increases acute kidney injury (AKI) risk. Aging increases hypohydration-induced kidney dysfunction in males, but female aging studies are lacking. Therefore, we compared the effects of mild hypohydration on kidney function and AKI biomarkers in young (YF) and older female adults (OF). In a random crossover design, 17 YF (20-35 yr old) and 9 OF (55-75 yr old), who were apparently healthy, completed two hydration protocols with ≥1 wk washout:

Indexed as

Acute Kidney InjuryAgingDehydrationKidneyAdultAgedAge FactorsBiomarkersCross-Over StudiesCystatin CFemaleHumansInsulin-Like Growth Factor Binding ProteinsLipocalin-2Middle AgedOsmolar ConcentrationBiomarkersCystatin Cinsulin-like growth factor binding protein-related protein 1Insulin-Like Growth Factor Binding ProteinsLCN2 protein, humanLipocalin-2TIMP2 protein, humanTissue Inhibitor of Metalloproteinase-2acute kidney injurydehydrationfemale aginghypohydrationrenin-angiotensin-aldosterone system

Identifiers

PMID41758613
PMCPMC13010121

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.