ReviewNeoplasia (New York, N.Y.)2026
Microbial crosstalk along the oral-gut axis: organ-specific oncogenic adaptations of Porphyromonas gingivalis and Fusobacterium nucleatum.
Review in Neoplasia (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Programming the tumor microenvironment through microbiome-driven mechanisms.Frontiers in cellular and infection microbiology · 2026Review
- Rethinking gastric carcinogenesis: a multiscale ecological model of risk beyondFrontiers in microbiology · 2026Review
- MicroRNAs in periodontal disease: from pathogenic mechanisms and RANKL/OPG regulation to nanoparticle delivery and personalized medicine.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oral-gut microbiota axis is increasingly recognized as a critical bridge linking local infection to systemic diseases. Growing evidence demonstrates that oral microbes not only enter the gut via saliva, bloodstream, and direct migration but also successfully colonize under specific microenvironmental conditions, reshaping the local microbial ecosystem. Periodontal pathogens such as P. gingivalis and F. nucleatum drive gastrointestinal tumorigenesis through chronic inflammation, metabolite production, and signaling pathway reprogramming. Moreover, oral-gut microbial interactions reveal cancer-specific risk patterns, with distinct roles in esophageal, gastric, colorectal, and pancreatic cancers. This review not only highlights the key mechanisms by which oral microbes promote tumor development but also emphasizes their clinical potential as diagnostic biomarkers and therapeutic targets, offering novel directions for translational research on the oral-gut axis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.