Evidence map›Paper›PMID 41759523›Full record

ArticleStem cell reports2026

ASCL1 promotes nuclear shrinkage in transdifferentiation by suppressing NUP37.

Emily Fisher, Zhongjiao Jiang, Li Li, Gaurav Chhetri, Komal Saleem, Zhen Yan, Jian Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emily FisherDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, USA; Research Department, Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, USA.
Zhongjiao JiangDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, USA.
Li LiDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, USA.
Gaurav ChhetriDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, USA.
Komal SaleemDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, USA.
Zhen YanDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, USA.
Jian FengDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, USA; Research Department, Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, USA. Electronic address: jianfeng@buffalo.edu.

Funding

Molecular Segregation of Parkinson’s Disease by Patient-Derived NeuronsR01NS113763 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FENG, JIAN · 2020 to 2024
$2.6M
Epigenetics-Based Autism Treatment with Animal Models and Human Stem CellsR01NS127728 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI JIAN FENG, Zhen Yan · 2023 to 2026
$2.5M
BLRD VA I01 BX002452NINDS NIH HHS R01 NS113763NINDS NIH HHS R01 NS127728
6 · The paper itself

Abstract

Despite the central role of the nucleus in the cell, it remains unclear what determines nuclear size. Previous studies suggest a correlation between nuclear and cell size. However, many neurons have massive axon arbors, while maintaining a typical nuclear size. Here, we show a marked reduction of nuclear, but not cell, size during the direct conversion of human fibroblasts to induced neurons by ASCL1, miR124-9-9

Indexed as

Basic Helix-Loop-Helix ProteinsCell NucleusCell TransdifferentiationNuclear Pore Complex ProteinsFibroblastsHumansInduced Pluripotent Stem CellsNeuronsNuclear PorePromoter Regions, GeneticASCL1 protein, humanBasic Helix-Loop-Helix ProteinsNuclear Pore Complex ProteinsASCL1Direct neuronal reprogramminginduced neuronsnuclear pore complexnuclear shrinkagenucleoporinNUP37transdifferentiation

Identifiers

PMID41759523
PMCPMC12985393

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.