Evidence mapPaperPMID 41759525Full record

ArticleStem cell reports2026

What we thought we knew about TNF-And what we now must re-learn.

Alexandra Rundberg Nilsson

Abstract read
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Alexandra Rundberg NilssonLund Stem Cell Center, Lund University, Lund, Sweden; Division of Molecular Medicine and Gene Therapy, Institution for Laboratory Medicine, Lund University, Lund, Sweden. Electronic address: alexandra.rundberg_nilsson@med.lu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor necrosis factor (TNF) was long cast as a hematopoiesis villain, driving bone marrow and hematopoietic stem cell (HSC) suppression. We now see that TNF's effects are cell type-, context-, and time-dependent. Rather than being simply "bad," TNF can prune progenitors while transiently reprogramming HSCs without sacrificing long-term regenerative capacity.

Indexed as

Hematopoietic Stem CellsTumor Necrosis Factor-alphaAnimalsHematopoiesisHumansTumor Necrosis Factor-alpha

Identifiers

PMID41759525
PMCPMC12985356

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.