Lipid droplet-associated proteins: Roles in cardiovascular diseases.

Zhongyang Yu, Meng Zhao, Hongyue Xu, Xiaoxing Jin, Ji Sun

Abstract readReview

In one paragraph

Review in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhongyang YuState Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China; Shanghai Frontiers Center of Nanocatalytic Medicine, Tongji University, Shanghai, China; Department of Pathology and Pathophysiology, School of Medicine, Tongji University, Shanghai, China; Clinical Center for Heart Disease Research, Tongji University, Shanghai, China; Shanghai Arrhythmia Research Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Meng ZhaoState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.

Hongyue XuState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.

Xiaoxing JinDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China; Department of Cardiovascular Medicine, Fifth Affiliated Hospital of Sun Yat-sen University, Zhu Hai, P.R. China. Electronic address: xiaoxingjinzs@foxmail.com.

Ji SunDepartment of Cardiology of Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou Henan, P.R. China. Electronic address: sunjisunyatsen@aliyun.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality worldwide. In the cardiovascular system, lipids serve as a primary energy source, and dysregulated lipid metabolism has been observed in many CVDs. Lipid droplets (LDs) are organelles that store lipids, including triglycerides and cholesterol. The biogenesis and lipolysis of LDs broadly influence lipid metabolism in cells in the cardiovascular system and contribute to CVDs. LDs homeostasis is modulated by lipid droplet-associated proteins (LDAPs), such as PLINs, CIDEs, BSCL2, ABHD5, and Rab18. These proteins have also been reported to be involved in various CVDs. To our knowledge, this is the first review to systematically elucidate the associations between LDAPs and CVDs. Here, we summarize the roles of LDAPs in CVDs and discuss them in detail.

Indexed as

Cardiovascular DiseasesLipid Droplet Associated ProteinsLipid DropletsAnimalsHumansLipid MetabolismLipid Droplet Associated Proteinscardiovascular diseaseslipid dropletslipid droplets associated proteins

Identifiers

PMID41759583

DOI10.1016/j.jlr.2026.101010

PMCPMC13122323

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.