Evidence map›Paper›PMID 41759587›Full record

ReviewJournal of food protection2026

Reoccurring, Emerging, and Persisting (REP) Strains: A Framework for Surveillance and Investigation of Pathogens of Public Health Importance.

Matthew E Wise, Michael Vasser, Jennifer Adams, Jennifer Beal, Amanda Conrad, Andrea Cote, Zachary Ellison, Gamola Z Fortenberry, Louise Francois Watkins, Laura Gieraltowski and 9 more

Abstract readReview
In one paragraph

Review in Journal of food protection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Matthew E WiseU.S. Centers for Disease Control and Prevention, United States. Electronic address: cxx4@cdc.gov.
Michael VasserU.S. Centers for Disease Control and Prevention, United States.
Jennifer AdamsAssociation of Public Health Laboratories, United States.
Jennifer BealU.S. Food and Drug Administration, United States.
Amanda ConradU.S. Centers for Disease Control and Prevention, United States.
Andrea CoteU.S. Department of Agriculture Food Safety and Inspection Service, United States.
Zachary EllisonU.S. Centers for Disease Control and Prevention, United States; ASRT, Inc, United States.
Gamola Z FortenberryU.S. Department of Agriculture Food Safety and Inspection Service, United States.
Louise Francois WatkinsU.S. Centers for Disease Control and Prevention, United States.
Laura GieraltowskiU.S. Centers for Disease Control and Prevention, United States.
Kelley B HiseU.S. Centers for Disease Control and Prevention, United States.
Molly LeeperU.S. Centers for Disease Control and Prevention, United States.
Megin NicholsU.S. Centers for Disease Control and Prevention, United States.
Doug NoveroskeU.S. Department of Agriculture Food Safety and Inspection Service, United States.
Grace PedersonU.S. Centers for Disease Control and Prevention, United States; Great Hill Solutions, United States.
James B PettengillU.S. Food and Drug Administration, United States.
Caroline SnyderU.S. Centers for Disease Control and Prevention, United States.
Jamie WasilenkoU.S. Department of Agriculture Food Safety and Inspection Service, United States.
Heather A CarletonU.S. Centers for Disease Control and Prevention, United States.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Acute outbreaks represent only a small fraction of all reported foodborne illness in the United States. Increasing identification of genetically related bacterial strains that cause human illness over periods much longer than traditional outbreaks necessitates a novel framework for understanding and investigating these reoccurring, emerging, and persisting (REP) strains. We describe the evolution of bacterial subtyping methods, from traditional serotyping to whole genome sequencing, which has substantially enhanced the ability to group together illnesses that are likely linked to a common food, animal, or environmental source. The proposed REP strain framework categorizes strains based on the epidemiological pattern of human illnesses: reoccurring strains cause periodic outbreaks, emerging strains demonstrate increasing incidence, and persisting strains consistently cause illnesses over time. We present case studies of six REP strains being tracked by health and regulatory agencies in the United States, including by PulseNet, the national molecular subtyping network for surveillance of bacterial enteric infections. These examples illustrate the diverse epidemiologic and genomic characteristics of REP strains and the opportunity they present to better understand how pathogens move between humans, foods, animals, and the environment. Effective monitoring and control of REP strains requires interdisciplinary collaboration among public health and regulatory agencies, academia, and industry to develop innovative investigational approaches that extend beyond traditional outbreak response. Investigation of REP strains can provide a better understanding of the drivers of illnesses that are not part of recognized outbreaks. Further, it has the potential to provide insights into pathogen transmission pathways that can inform broader prevention strategies aimed at reducing the overall burden of foodborne and other infections.

Indexed as

Disease OutbreaksPublic HealthAnimalsFoodborne DiseasesFood MicrobiologyHumansUnited StatesFoodborne diseasesGenomicsWhole−genome sequencingZoonotic diseases

Identifiers

PMID41759587
PMCPMC13643855

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.