ArticleBrain stimulation
Network-targeted TMS modulates nicotine craving and default mode network connectivity in psychotic disorders.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
objectiveTobacco use is the top preventable cause of early mortality in schizophrenia, but the underlying pathophysiology remains unknown. In schizophrenia, small studies have linked default mode network (DMN) organization to tobacco use and showed that nicotine normalizes DMN disorganization. We sought to 1) validate the relationship between DMN organization and tobacco use using a large psychosis-spectrum sample (Bipolar-Schizophrenia Network on Intermediate Phenotypes 2, B-SNIP2); and 2) test if targeting this network with single and multiple sessions of transcranial magnetic stimulation (TMS) would affect craving.
methodsIn B-SNIP2 (n = 596), we tested associations between DMN connectivity and tobacco use. In the Single Session DMN-targeted TMS study, 10 individuals received single TMS sessions (intermittent theta burst stimulation, iTBS; continuous theta burst stimulation, cTBS; sham) with pre-/post-neuroimaging and craving assessment. In the Accelerated, Multi-Session DMN-targeted cTBS study, 12 individuals received 5 cTBS sessions with pre-/post-neuroimaging and craving assessment.
resultsIn B-SNIP2 (n = 596), current smokers had lower DMN connectivity than former (p = .017) and never smokers (p = .021). These differences were also observed in the psychosis group (current vs. former p = .044; current vs. never p = .011). In the Single Session DMN-targeted TMS study (n = 10), there was a treatment∗time interaction (p = .020) where iTBS increased craving (p
conclusionsWe identified a potential mechanism of nicotine use in psychosis and demonstrated that engaging this target reduces craving, suggesting a novel target for nicotine interventions in psychosis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.