SynthesisIn vivo (Athens, Greece)
Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases.
Synthesis in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Polyphenols and Cardiovascular Health: Emerging Relevance for Blueberries, Grapes, and Red-Fleshed Table Grapes.Nutrients · 2026Review
- Natural Bioactive Compounds Targeting Gut Barrier Integrity and Metabolic Endotoxemia in Cardiometabolic Disease: Mechanistic Insights and Translational Perspectives.Molecules (Basel, Switzerland) · 2026Review
- Sustainable Recovery and Biofunctional Characterization of Polyphenol-Rich Extracts from Norway Spruce, Chestnut Wood, and Pomegranate By-Products.Foods (Basel, Switzerland) · 2026Article
- Resveratrol in Oral Squamous Cell Carcinoma: Preclinical Evidence and Translational Opportunities.Oncology research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimResveratrol, a polyphenolic compound found in grapes, berries, and peanuts, has been linked to antioxidant, anti-inflammatory, and vasoprotective effects. Yet, evidence from randomized controlled trials (RCTs) remains inconsistent, and the quality, dosage, and cost of commercial resveratrol products vary considerably, raising uncertainty about their true efficacy. A comprehensive synthesis of its effects on obesity-related non-communicable diseases (NCDs) is therefore warranted. Given that obesity is a key driver of metabolic dysregulation underlying diabetes, cardiovascular disease, and fatty liver disease, clarifying resveratrol's potential in overweight and obese populations is of particular importance. MATERIALS AND
methodsWe systematically searched PubMed, Embase, the Cochrane Library, and Web of Science for RCTs published up to July 2025 that evaluated resveratrol supplementation in adults with obesity-related metabolic disorders or associated risk factors. Study selection and data extraction followed PRISMA 2020 guidelines. Pooled estimates were calculated using random-effects models, and heterogeneity was assessed with the
resultsForty RCTs involving 2551 participants were included. Resveratrol significantly reduced the homeostatic model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) cholesterol, systolic blood pressure (SBP) and diastolic blood pressure (DBP), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). No consistent changes were observed for high-density lipoprotein (HDL) cholesterol, body weight (BW), body mass index (BMI), fat mass, hip circumference (BC), waist circumference (WC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), or liver fat. To our knowledge, this meta-analysis includes the largest number of RCTs to date and the most comprehensive coverage of obesity-related metabolic and inflammatory endpoints. Effect sizes varied by intervention dose and duration.
conclusionResveratrol supplementation shows modest benefits on selected metabolic and inflammatory parameters but does not exert broad effects across all obesity-related NCD risk factors. Its potential role may be most relevant in populations with metabolic disturbances. Large-scale, long-term RCTs are warranted to clarify optimal dosing strategies and establish its utility in the prevention and management of obesity-related non-communicable diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.