ArticleIn vivo (Athens, Greece)
Cardiovascular Adverse Events Associated With Carfilzomib, Bortezomib, and Ixazomib: A Disproportionality Analysis Using the Japanese Adverse Drug Event Report Database With Anticancer Agents as the Reference Group.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Integrative Cross-platform Analysis of Kinase Inhibitor Effects on Statin-relevant Cardioprotective Pathways in Human Cardiomyocytes.Cancer genomics & proteomicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimIn this study, we aimed to evaluate the cardiovascular adverse event (CVAE) signals associated with three proteasome inhibitors (PIs), carfilzomib, bortezomib, and ixazomib, using the Japanese Adverse Drug Event Report (JADER) database, with anticancer agents as a reference. PATIENTS AND
methodsSpontaneous adverse event reports restricted to anticancer agents were extracted from the JADER database between April 2004 and March 2025. A disproportionality analysis was conducted for six predefined CVAE categories based on narrow Standardized MedDRA Queries. Additional analyses were stratified by age (≥70
resultsIn total, 12,181 CVAE reports were identified: 2,303 for carfilzomib, 6,851 for bortezomib, and 3,027 for ixazomib. The overall analysis detected multiple CVAE signals for carfilzomib and bortezomib, including cardiac failure and arrhythmia, whereas no signals were detected for ixazomib. The age-stratified analysis performed revealed new signals that were not observed overall, including venous thromboembolism in older adult patients receiving carfilzomib, cardiomyopathy in those receiving bortezomib, and cardiac failure in those receiving ixazomib. Sex-stratified analysis identified male-specific signals, including thromboembolic and arrhythmic events for carfilzomib, cardiomyopathy for bortezomib, and both cardiac failure and cardiomyopathy for ixazomib. The JADER database analysis identified multiple CVAE signals for carfilzomib and bortezomib, along with new age- and sex-specific signals not observed in the overall population.
conclusionThese findings highlight the potential influence of patient demographics on CVAE risk and support tailored monitoring strategies for patients receiving PIs, particularly older adult and male patients.
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