Evidence map›Paper›PMID 41760544›Full record

ArticleLife science alliance2026

Tissue-specific I-Smad mechanisms revealed by structure-function analysis in

Ania M Simoncek, Steven J Sviridoff, Joshua N Hays, Noah J Graichen, Mikolaj J Sulkowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Ania M SimoncekBiology Department, Southern Connecticut State University, New Haven, CT, USA.ORCID 0009-0006-0256-4266
Steven J SviridoffBiology Department, Southern Connecticut State University, New Haven, CT, USA.
Joshua N HaysBiology Department, Southern Connecticut State University, New Haven, CT, USA.
Noah J GraichenBiology Department, Southern Connecticut State University, New Haven, CT, USA.
Mikolaj J SulkowskiBiology Department, Southern Connecticut State University, New Haven, CT, USA sulkowskim1@southernct.edu.ORCID 0009-0000-6282-3561

Funding

DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Investigating the function of localized BMP signaling at neuromuscular synapsesR15NS116630 · NINDS · SOUTHERN CONNECTICUT STATE UNIVERSITY · PI SULKOWSKI, MIKOLAJ · 2021 to 2021
$378k
NIGMS NIH HHS R01 GM129325NIH HHS P40 OD010949NINDS NIH HHS R15 NS116630
6 · The paper itself

Abstract

Inhibitory Smads (I-Smads) regulate TGF-β/BMP signaling through multiple distinct mechanisms, but whether different tissues preferentially employ specific mechanisms remains unknown. To address this question, we performed structure-function analyses of the

Indexed as

Drosophila ProteinsRepressor ProteinsSmad ProteinsAnimalsBone Morphogenetic ProteinsDrosophilaDrosophila melanogasterGene Expression Regulation, DevelopmentalOrgan SpecificityProtein BindingProtein DomainsSignal TransductionSmad6 ProteinSmad7 ProteinStructure-Activity RelationshipTransforming Growth Factor betaBone Morphogenetic ProteinsDad protein, DrosophilaDrosophila ProteinsRepressor ProteinsSmad6 ProteinSmad7 ProteinSmad ProteinsTransforming Growth Factor beta

Identifiers

PMID41760544
PMCPMC12948492

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.