ArticleJournal of managed care & specialty pharmacy2026
Real-world 6-month persistence, adherence, and effectiveness of GLP-1 medications for overweight and obesity in a Medicaid population.
Article in Journal of managed care & specialty pharmacy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Discontinuation of glucagon-like peptide-1 receptor agonists among US adults: A national survey.Journal of managed care & specialty pharmacy · 2026Article
- Rates of, Reasons for, and Reactions to Discontinuation of GLP-1 Receptor Agonists: A Narrative Review.Diabetes, obesity & metabolism · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlucagon-like peptide-1 (GLP-1) receptor agonists, including a dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonist, have expanded treatment options for overweight and obesity. However, real-world data within Medicaid populations remain limited.
objectiveTo assess 6-month persistence, adherence, and effectiveness of GLP-1 and GLP-1/GIP therapies among Massachusetts Medicaid (MassHealth) members.
methodsThis retrospective, claims-based analysis identified continuously enrolled MassHealth adults, with or without diabetes, initiating GLP-1 or GLP-1/GIP treatment with semaglutide (Wegovy) or tirzepatide (Zepbound) between July 1, 2024, and December 31, 2024. The co-primary outcomes were persistence, defined as no more than 56 days between fills, and adherence, defined as proportion of days covered (PDC) of at least 80%. A key secondary outcome examined the rate at which a subgroup of members achieved at least a 5% reduction in body weight from baseline as documented on prior authorization (PA) recertification at 6 months.
resultsAmong 7,493 members, rates of persistence and adherence to treatment were 60.8% and 60.1%, respectively. Member-specific factors associated with lower rates of persistence and adherence included male sex, age (<40 years), diabetes, and a lack of weight-related comorbidities. Among a subgroup of members on tirzepatide, semaglutide, or with exposure to both, 86.5% of members had at least a 5% reduction in body weight from baseline at 6 months.
conclusionsAt 6 months, MassHealth members showed moderate persistence and adherence to GLP-1 or GLP-1/GIP treatment. Tirzepatide and semaglutide were effective in producing significant weight loss at 6 months among a subgroup of highly persistent and adherent members.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.