Evidence map›Paper›PMID 41760662›Full record

ArticleNature communications2026

Genome-wide analysis of cardiac ventricular phenotypes reveals novel loci and therapeutic targets for heart failure.

Hannah L Nicholls, Jose D Vargas, Mihir M Sanghvi, Hyo-Suk Ahn, C Anwar A Chahal, Mohammed Y Khanji, Steffen E Petersen, Patricia B Munroe, Nay Aung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hannah L NichollsWilliam Harvey Research Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-3480-7852
Jose D VargasWilliam Harvey Research Institute, Queen Mary University of London, London, UK.
Mihir M SanghviWilliam Harvey Research Institute, Queen Mary University of London, London, UK.
Hyo-Suk AhnThe Catholic University of Korea, Uijeongbu St. Mary's Hospital, Seoul, Korea.ORCID http://orcid.org/0000-0001-9531-7286
C Anwar A ChahalWilliam Harvey Research Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-7825-8827
Mohammed Y KhanjiWilliam Harvey Research Institute, Queen Mary University of London, London, UK.
Steffen E PetersenWilliam Harvey Research Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0003-4622-5160
Patricia B MunroeWilliam Harvey Research Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-4176-2947
Nay AungWilliam Harvey Research Institute, Queen Mary University of London, London, UK. n.aung@qmul.ac.uk.ORCID http://orcid.org/0000-0001-5095-1611

Funding

British Heart Foundation (BHF) FS/CRTF/22/24353British Heart Foundation (BHF) PG/14/89/31194RCUK | Medical Research Council (MRC) MR/X020924/1
6 · The paper itself

Abstract

Left and right ventricular imaging measures are essential for heart failure diagnosis and prognostication, yet their genetic architecture remains underexplored. We conduct genome-wide association analyses of twenty left and right cardiovascular magnetic resonance phenotypes in 56,509 UK Biobank participants, including conventional measurements (e.g., volumes/ejection fraction) and novel parameters (left ventricular global function index and myocardial contraction fraction). We identify 200 loci associated with at least one phenotype (P < 5×10

Indexed as

Genome-Wide Association StudyHeart FailureHeart VentriclesAgedCyclic Nucleotide Phosphodiesterases, Type 3FemaleGenetic LociGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMagnetic Resonance ImagingMaleMiddle AgedPhenotypePolymorphism, Single NucleotideVentricular Function, LeftCyclic Nucleotide Phosphodiesterases, Type 3

Identifiers

PMID41760662
PMCPMC13066029

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.