ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026
Evaluating temozolomide for pediatric adamantinomatous craniopharyngiomas using microspheroid-based drug screening.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Prediction of personalized therapeutic response in pediatric clivus chordoma: chemoresistance test.Journal of cancer research and clinical oncology · 2026Article
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15 authors.
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Abstract
purposePediatric adamantinomatous craniopharyngioma (ACP) is the most common tumor of the diencephalic-pituitary axis in children. Although histologically benign, pediatric ACP is frequently associated with substantial endocrine dysfunction and neurological complications. The gold-standard treatment is complete surgical resection; however, because of the tumor's location, total removal is often not feasible. Consequently, several authors recommend radiotherapy as an adjuvant option. Nevertheless, partial resections are frequently followed by recurrence, and repeated surgical interventions increase morbidity and impair quality of life. Thus, adjuvant therapeutic strategies capable of controlling this tumor should be encouraged.
methodsWe analyzed seven fresh tumor specimens ACP from patients < 18 years of age using a chemoresistance platform (Bioverso Test, Ziel Biosciences, São Paulo, Brazil). These cases demonstrated widespread resistance to most chemotherapeutic agents tested. Temozolomide (500 µM) was the only drug that showed consistent and significant sensitivity.
resultsBased on these findings, we initiated treatment in a 14-year-old patient with recurrent ACP who had previously undergone multiple surgical procedures and radiotherapy. The tumor involved the left cavernous sinus and extended into the sphenoid sinus. Clinically, the patient was amaurotic and presented with panhypopituitarism. The patient received temozolomide (200 mg/m
conclusionThese findings suggest that temozolomide may represent a promising therapeutic option for controlling ACP.
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