Evidence map›Paper›PMID 41760882›Full record

ArticleScientific reports2026

Applications of Opuntia ficus-indica (L.) mill seed oil from eastern morocco including chemical profiling, antibacterial activity, and docking.

Salma Kadda, Oussama Khibech, El Hassania Loukili, Raffaele Conte, Khalil Azzaoui, Sabir Ouahhoud, Belkheir Hammouti, Hana Caid Serghini, Taibi Ben Hadda, Shehdeh Jodeh and 1 more

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Salma KaddaEuromed University of Fes (UEMF), Fez, 30000, Morocco. salma.kada25@gmail.com.
Oussama KhibechFaculty of sciences, department of Chemistry, Laboratory of Applied and Environmental Chemistry (LCAE), Mohammed Premier University, University Mohammed Premier, Oujda, Morocco.
El Hassania LoukiliEuromed University of Fes (UEMF), Fez, 30000, Morocco.
Raffaele ConteResearch Institute on Terrestrial Ecosystems (IRET)-CNR, Via Pietro Castellino 111, Naples, 80131, Italy.
Khalil AzzaouiEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences, Sidi Mohamed Ben Abdellah University, Fes, 30000, Morocco.
Sabir OuahhoudFaculty of Medicine and Pharmacy, Sultan Slimane University, Beni Mellal, Morocco.
Belkheir HammoutiEuromed University of Fes (UEMF), Fez, 30000, Morocco.
Hana Caid SerghiniLaboratory of Plants & Microorganisms Biology, Faculty of Sciences, Oujda - University Mohammed Premier, Oujda, BP-717, 60000, Morocco.
Taibi Ben HaddaEuromed University of Fes (UEMF), Fez, 30000, Morocco.
Shehdeh JodehDepartment of Chemistry, An-Najah National University, P.O. Box 7, Nablus, Palestine. sjodeh@najah.edu.
Abdelmajid BelabedLaboratory of Plants & Microorganisms Biology, Faculty of Sciences, Oujda - University Mohammed Premier, Oujda, BP-717, 60000, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study reports the chemical profiling and antimicrobial potential of Opuntia ficus-indica seed oil from Eastern Morocco, with emphasis on pharmacologically relevant constituents and valorization of an underexploited by-product. Seed oil was obtained by cold mechanical pressing and characterized using GC–MS (fatty acids and volatile profile), HPLC–DAD (tocopherols), and UHPLC–MS/MS (phenolic constituents). The oil exhibited a PUFA-rich profile dominated by linoleic acid (73.94%), with palmitic and stearic acids as major saturated components, while oleic acid was not detected under our analytical conditions. Tocopherol analysis revealed a high γ-tocopherol level (657.52 mg/kg). UHPLC–MS/MS enabled annotation of multiple phenolic compounds, including arbutin and kaempferol as major constituents. In vitro antibacterial assays showed no inhibition against Staphylococcus aureus and Streptococcus spp. (inhibition zone < 7 mm), whereas moderate-to-high activity was observed against Escherichia coli (11.6 ± 0.64 mm) and Klebsiella spp. (15.6 ± 0.51 mm). In silico POM analysis supported favorable drug-likeness/toxicological profiles for arbutin and kaempferol. Overall, these results support O. ficus-indica seed oil as a chemically rich natural matrix with promising antioxidant and antibacterial potential.

Indexed as

Anti-Bacterial AgentsOpuntiaPlant OilsSeedsAntioxidantsChromatography, High Pressure LiquidFatty AcidsGas Chromatography-Mass SpectrometryKaempferolsMicrobial Sensitivity TestsMolecular Docking SimulationMoroccoStaphylococcus aureusTandem Mass SpectrometryTocopherolsAnti-Bacterial AgentsAntioxidantsFatty AcidskaempferolKaempferolsPlant OilsTocopherolsAntibacterial activityLinoleic acidOpuntia ficus-indicaPhenolic profilePOM analysis, good health and wellbeingTocopherols

Identifiers

PMID41760882
PMCPMC12987923

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.